Registration Dossier
Registration Dossier
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EC number: 228-507-4 | CAS number: 6284-43-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxicity up to the limit of water solubility (WS < 0.15 mg/L)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the acute toxicity of 2,3-dihydroxypropyl 12-hydroxyoctadecanoate (CAS No. 6284-43-1) to fish species are available. Therefore, toxicity data from a structurally related analogue substance, castor oil hydrogenated (CAS No. 8001-78-3) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both substances are esters formed from the combination of C18OH fatty acids and glycerol. The behaviour of these substances in the water phase is expected to be very similar based on low water solubility (< 0.15 and < 0.05 mg/L) and comparable log Pow (> 5) values. Based on this information, reading-across from castor oil hydrogenated to 2,3-dihydroxypropyl 12-hydroxyoctadecanoate is justified.
A study was conducted with castor oil hydrogenated (CAS No. 8001-78-3) according to ISO 7346-1. Fish (Danio rerio) were exposed for 96 hours to the test substance within a semi-static water regime, at nominal concentrations of 1000, 3000 and 10000 mg/L. No mortality was observed at any of the tested concentrations and therefore the LC50 (96 h) was determined to be > 10,000 mg/L (nominal concentration).
Based on the results obtained for the structurally related analogue substance (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), no acute toxicity of2,3-dihydroxypropyl 12-hydroxyoctadecanoateto fish species up to the limit of its water solubility (< 0.15 mg/L) is expected.
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