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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data contained in EU risk assessment report of the substance - credibility is assumed. (In the EU report it is referred to the original study of Darmer et al.(1982, 1984) and Lu et al. (1987))

Data source

Referenceopen allclose all

Reference Type:
other: EU risk assessment report
Title:
No information
Author:
Federal Institute for Occupational Safety and Health, Division for Chemicals and Biocides Regulation, Germany
Year:
2009
Bibliographic source:
European Union Risk Assessment Report, 4-tert-butylbenzoic acid, CAS No: 98-73-7, EINECS No: 202-696-3, p. 47, Final Approved Version, July 2009
Reference Type:
study report
Title:
Unnamed
Year:
1982
Reference Type:
publication
Title:
Toxicity in rats following single 4 hour or 7-day repeated inhalation of para-tertiary butyl benzoic acid dust.
Author:
Darmer et al.
Year:
1984
Bibliographic source:
Darmer KI, Patterson DR, Lu CC and Gardiner TH (1984). Toxicity in rats following single 4 hour or 7-day repeated inhalation of para-tertiary butyl benzoic acid dust. The Toxicologist, 4, 191
Reference Type:
publication
Title:
Testicular effects induced by dermal or inhalation exposure to para-tertiary butyl benzoic acid (ptBBA) in Fischer 344 rats.
Author:
Lu et al.
Year:
1987
Bibliographic source:
Lu CC, Cagen SZ, Darmer KI and Patterson DR (1987). Testicular effects induced by dermal or inhalation exposure to para-tertiary butyl benzoic acid (ptBBA) in Fischer 344 rats. J. Am. Coll. Toxicol., 6, 233-243.

Materials and methods

Principles of method if other than guideline:
Exposition of rats to dust of PTBBA. Determination of acute inhalation toxicity (LC50).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-tert-butylbenzoic acid
EC Number:
202-696-3
EC Name:
4-tert-butylbenzoic acid
Cas Number:
98-73-7
Molecular formula:
C11H14O2
IUPAC Name:
4-tert-butylbenzoic acid
Test material form:
other: dust
Details on test material:
- Analytical purity: 99.4 %

Test animals

Species:
rat
Strain:
other: Fischer
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1.802 mg/L air

Any other information on results incl. tables

At the highest concentration of 1.802 mg/l 2/6 males and 1/6 females died. This indicates that the LC50 is > 1.802 mg dust/l. However, other major toxicological effects were seen at all concentrations tested and a No-Effect-Level for a single four hour exposure could not be determined. At the lowest concentration of 0.495 mg/l effects on testes, in spinal cord and on rate of body weight gain were noted. Testicular effects were characterised among others by decreased sperm counts and microscopic lesions including reduction of tubular multinucleated cells. The forelimb neuropathy was described microscopically as multifocal poliomyelopathy. Decreased rate of body weight gain was observed in both sexes on days 4 and 14 exposed to all dose levels of PTBBA

Applicant's summary and conclusion

Conclusions:
According to the cited results the test substance provided as dust to male and female rats has a LC50 at greater than 1.802 mg dust/L.