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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-696-3 | CAS number: 98-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
EU risk assessment (2009), p. 46-47:
Summary of toxicokinetics, metabolism and distribution: There are no data available on the toxicokinetics, metabolism and distribution of 4-tertbutylbenzoic acid after inhalation, oral and dermal exposure in animals or humans. Taking into account the physico-chemical properties of PTBBA (molecular weight 178 g/mol, water solubility of 47.1 mg/l, log Pow of 3.4, and vapour pressure of 0.057 Pa), the state of ionisation and available toxicological information an extent of absorption of 100% via inhalation, dermal and oral exposure will be assumed.
EU risk assessment (2009), p.34:
PBT-assessment
PTBBA is according to standard ready biodegradability tests not readily degradable (Shell
Research Limited, 1984a). Other data available indicate that PTBBA might be inherently
biodegradable (see chapter 3.1.3). As the present data cannot be used to judge whether the
substance is inherently biodegradable or not, the screening P-criterion can be considered to be
fulfilled.
For PTBBA, no experimental results on bioaccumulation are available. The octanol-water
partitioning coefficient for the undissociated substance (logKow = 3.4) is below the screening
criterion logKow of 4.5. As PTBBA is present in the environmentally relevant pH-range
mainly in ionized form, bioaccumulation potential can be expected to be low. It can thus be
concluded that PTBBA does not fulfil the screening B-criterion.
Only acute data on the aquatic ecotoxicity of PTBBA are available (see chapter 3.2.1).
Information on the toxicity of organisms in other compartments has not been presented. The
lowest acute effect value (for goldfish; 96h-LC50 = 4 mg l-1) is higher than the T-screening
criterion of 0.1 mg l-1.
PTBBA fulfils the screening P-criterion, but not the screening criteria for bioaccumulation
and ecotoxicity. Therefore, PTBBA can be considered as no PBT.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
In respect of toxicokinetics, the EU risk assessment report states that the substance is likely to be fully absorbed by the body. At the same time it is not considered a PBT substance. However, the P-criterion is met as the substance is not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.