Sodium 2-(2-dodecyloxyethoxy)ethyl sulphate

Endpoint summary

Additional information

Short-term toxicity to fish

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	25 mg/l	mortality	96 hrs	Danio rerio	Study Report for target chemical
2	LC50	102.59 mg/l	mortality	96 hrs	Danio rerio	Predicted data for target chemical
3	LC50	46 mg/l	mortality	48 hrs	Oryzias latipes	Data from publication for CAS NO 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 25 to 102.59mg/l in 96 hrs and 48 hrs on the basis of mortality effect . But the BCF value ofSodium 2-(2-dodecyloxyethoxy) ethyl sulphatereported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate does not exhibit short term toxicity to fish (Oryzias latipes,Danio rerio)

 

Long term toxicity to fish:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static fresh water system, the NOEC value for the substance is estimated to be36.507mg/l for fish for 28 days of exposure duration.Since, the test substance is redialy degradable in aquatic environment, it can be concluded that the test chemical can be considered as non-toxic to fish at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria. 

Short-term toxicity to aquatic invertebrates

Based on the various studies available with Klimish rating 2 for target chemical CAS NO 3088-31-1 and the read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	86.09 mg/l	mortality	48 hrs	Daphnia magna	Predicted data for target chemical
2	LC50	7.2 - 154 mg/L.	mortality	24 hrs	Artemia salina	Data from publication for CAS no 151-21-3
3	LC50	10.9 – 29.4 mg/L.	mortality	24 hrs	Brachionus plicatilis	Data from publication for CAS no 151-21-3
4	LC50	5.1 – 84 mg/L.	mortality	24 hrs	Daphnia magna	Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 5.1 to 154 mg/l in a 24 to 48 hrs study on the basis of mortality effect. But the BCF value of Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus according to CLP criteria of aquatic classification it is concluded that the substance Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate is not toxic to aquatic invertebrate (Daphnia magna, Artemia salina and Brachionus plicatilis)

 

Long term toxicity to aquatic invertebrate:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrate was predicted for test substance . On the basis of effects observed in a static freshwater system, the NOEC value for the test substance is estimated to be 20.059 mg/l for aquatic invertebrate for 21 days of exposure,The test substance is redialy biodegradable in aquatic environment it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	EC50	115.072mg/l	growth rate	72 hrs	Pseudokirchnerella subcapitata	Predicted data for target chemical
2	EC50	100 mg/l	Cell changes	24 hrs	Laminaria hyperborea	Data from publication for CAS no 9004-82-4
3	EC50	117mg/l	growth inhibition	4 days	Seleriastrum Capricornutum	Data from publication for CAS no 151-21-3
4	EC50	1550mg/l	growth inhibition	6 hrs	Seleriastrum Capricornutum	Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in range of100 to1550 mg/l in 6 hrs to 72 hrs study. Thus considering CLP Criteria for aquatic classification of the substance, it is concluded that Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate does not exhibit toxicity to green algae (Pseudokirchnerella subcapitata, Laminaria hyperborea  and Seleriastrum Capricornutum.)

Toxicity to microorganisms

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3088-31-1 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	IC50	5888.99 mg/l	growth inhibition	16 hrs	aerobic microorganisms	Predicted data for target chemical
2	EC50     EC50	135 mg/l     188 mg/l	growth inhibition	3 hrs     0.5 hrs	activated sludge	Data from publication for CAS no 151-21-3

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that IC50 value is expected to be in 5888.99mg/l and EC50 value was found to be in the range of 135 to 188 mg/l in 0.5 to 16 hrs study.