Registration Dossier
Registration Dossier
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EC number: 237-695-7 | CAS number: 13927-71-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- Mathematical simulation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Data source
Referenceopen allclose all
- Title:
- IH SkinPerm (v2.04)
- Author:
- AIHA
- Year:
- 2 018
- Bibliographic source:
- https://www.aiha.org/get-involved/VolunteerGroups/Pages/Exposure-Assessment-Strategies-Committee.aspx
- Reference Type:
- publication
- Title:
- Dermal absorption of chemicals: estimation by IH SkinPerm
- Author:
- Tibaldi R, ten Berge W, Drolet D
- Year:
- 2 014
- Bibliographic source:
- J Occup Environ Hyg.,11(1):19-31
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- IH SkinPerm mathematical tool for estimating dermal absorption
Test material
- Reference substance name:
- Bis(dibutyldithiocarbamato-S,S')copper
- EC Number:
- 237-695-7
- EC Name:
- Bis(dibutyldithiocarbamato-S,S')copper
- Cas Number:
- 13927-71-4
- Molecular formula:
- C18H36CuN2S4
- IUPAC Name:
- bis(dibutyldithiocarbamato-S,S')copper
Constituent 1
- Specific details on test material used for the study:
- Entrance data on the test substance :
-temperature : 25°C
-Molecular weight : 472.28
-Vapour pressure : 6.4 x10^-12 Pa
-Water solubility : 0.001 mg/l
-Log kow : 4.73
-Density : 1100 mg/m3
-Melting point : 78 °C
Administration / exposure
- Details on in vitro test system (if applicable):
- Details of the model used as presented in the attached document.
Results and discussion
- Absorption in different matrices:
- Details of the results are presented in the attached document.
Percutaneous absorption
- Time point:
- 8 h
- Dose:
- 100
- Parameter:
- percentage
- Absorption:
- 0 %
Applicant's summary and conclusion
- Conclusions:
- According to the IH skin perm (QSAR), the dermal absorption of bis(dibutyldithiocarbamato-S,S')copper is 0.1%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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