Registration Dossier
Registration Dossier
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EC number: 214-185-2 | CAS number: 1111-78-0
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
It is technically not feasible to conduct a study to determine the partition coefficient n-octanol/water for the carbamate part.
An EPIsuite calculation gives a value of -1.88 for carbamic acid referring to the uncharged molecule.
A historical study with ammonium carbamate monitoring the ammonium content has -0.66 - -0.85 (depending on concentration) at 25°C and pH 9.1 as result.
Key value for chemical safety assessment
- at the temperature of:
- 20 °C
Additional information
In the guidance it is requested to measure at a pH value which maximises the potential for partition into n-octanol. This means for the anion carbamate it is to be measured in the acidic range. The carbamate ion is unstable in acidic medium and decomposes into ammonia and carbon dioxide. Even at weak acidic condition (acetic acid / acetate) a complete decomposition occurs in less than a second (Faurholt, 1921). (see also IUCLID chapter 5.1.2)
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