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EC number: 205-286-2 | CAS number: 137-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Adequacy of study:
- supporting study
- Study period:
- 1 - 31 October 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP certifying authority, Germany
- Type of method:
- flask method
- Water solubility:
- 16.5 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 96 - <= 120 h
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not determined, RSD 3.24%
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 September 2005- 6 April 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 0.018 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5
- Water solubility:
- 0.017 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- Thiram decomposes at pH 9 buffer solution
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 January - 22 February 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The department of health of the government of the United Kingdom
- Type of method:
- flask method
- Water solubility:
- 18.5 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 4
- Water solubility:
- 18 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- 19.1 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 7.11 - <= 7.15
- Remarks on result:
- other: purified water, pH
- Water solubility:
- 14.8 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 h
- Temp.:
- 20 °C
- pH:
- 10
- Remarks on result:
- other: a water solubility of 3.5 mg/L after 3 days was determined. Some hydroylsis might take place during the time.
Referenceopen allclose all
The result from the pH 10 buffered samples that had been mixed at 30 °C for 1, 2 and 3 days
was considerably lower than for the other solutions and the chromatograms showed
additional peaks which suggested hydrolysis at pH 10. Additional samples were therefore
prepared. Vials containing Thiram (15 mg) and pH 10 buffer solution (30 mL) were purged
with nitrogen, sealed and mixed at 20 °C for 1, 2 and 3 hours. After mixing at 20 °C the
samples were then processed immediately and diluted for analysis by the HPLC method.
The additional pH 10 buffered samples gave a water solubility result of 14.8 mg/L. This
should be considered to be a minimum solubility value since it cannot be certain that some
hydrolysis had not taken place prior to analysis.
The mean recoveries of Thiram from the method verification samples prepared at the 10% fortification level were as follows:
Media | Recovery (%) | RSD (%) |
pH 4 buffer solution | 104 | 1.4 |
pH 7 buffer solution | 102 | 1.7 |
pH 10 buffer solution | 95 | 8.4 |
Purified water | 105 | 0.4 |
Description of key information
18.5 mg/L at pH 4 and 20 °C
18.4 mg/L at pH 5 and 20 °C
17.1 - 18 mg/L at pH 7 and 20 °C
19.1 mg/L at pH 7.11-7.15 (purified water) and 20 °C
14.8 mg/L at pH 10 and 20 °C (hydrolysis might take place during the experimental period).
Key value for chemical safety assessment
- Water solubility:
- 19.1 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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