Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-036-1 | CAS number: 25214-70-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Aquatic algae and cyanobacteria are not the most sensitive species of the 3 trophic levels, therefore this trophic level is not used for the derivation ofthe aquatic PNEC.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 11 mg/L
- EC10 or NOEC for freshwater algae:
- 0.3 mg/L
Additional information
A full discussion on the justification on read-across of data for the 4,4´-isomer of MDA for oligomeric MDA in the scope of REACH is presented in section 7.6 of this CSR.
The Bayer AG study was given a reliability of 2 because of compliance with GLP although analytical monitoring was not performed. Results of the study include a selection of EC50 and NOEC values based both on "growth rate" and "area under the growth curve". However it should be noted that results elsewhere confirm that for 4,4'-MDA algae are not the most sensitive species of the three trophic levels of the base-set (fish, daphnia and algae).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
