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EC number: 448-300-4 | CAS number: 88642-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-01-22 to 2005-02-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.982 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Conclusions:
- The water solubility of the test item was determined to be 0.982 mg/L at 20 °C and pH 7.0.
- Executive summary:
The water solubility of the test item was determined according to OECD 105 (1995) using a column elution method based on a preliminary test showing the water solubility lower than 10 mg/L. The test was performed under GLP. The concentrations were analyzed via GC-MS after reaching equilibration state. The water solubility of the test item was determined to be 0.982 mg/L at 20 °C and pH 7.0. The solubility of test item was determined in water at neutral pH (distilled water being in equilibrium with atmospheric carbon dioxide) at 10, 20 and 30 °C. It showed that the water solubility of the test item is not dependent on temperature, but slightly dependent on pH-value.
Reference
Preliminary Test
Preliminary test in pure water (1000 g/L to 0.01 g/L)
Test Item |
total volume of water |
time of shaking |
remarks |
Approx. solubility |
100 |
0.1 |
10 |
not dissolved completely |
> 1000 |
100 |
0.5 |
10 |
not dissolvedcompletely |
1000 to 200 |
100 |
1 |
10 |
not dissolved completely |
200 to 100 |
100 |
2 |
10 |
not dissolved completely |
100 to 50 |
100 |
10 |
10 |
not dissolved completely |
50 to 10 |
100 |
100 |
1 [h] |
not dissolved completely |
10 to 1 |
100 |
1000 |
12 [h] |
not dissolved completely |
1 to 0.1 |
10 |
1000 |
72 [h] |
not dissolved completely |
< 0.01 |
Therefore, the approximate solubility of the test item was estimated to be below 0.01 g/L at 20 °C.
Main Test
The solubility of test item was determined in water at neutral pH (distilled water being in equilibrium with atmospheric carbon dioxide) at 10, 20 and 30 °C.
Solubility in water at neutral pH (distilled water being in equilibrium with atmospheric carbon dioxide) at 10, 20 and 30 °C.
Temperature [°C] |
10 |
20 |
30 |
pH |
5.60 |
5.56 |
5.61 |
Solubility [mg/L] |
0.719 |
0.705 |
0.706 |
In % of solubility at 20°C |
102 |
100 |
100 |
%/°C |
0.1 |
|
|
The pH dependency in the range of 4 — 10 was determined in buffered systems (0.05 M) at 20 °C.
pH |
4.00 |
7.03 |
9.02 |
Temperature [°C] |
20 |
20 |
20 |
Solubility [mg/L] |
0.863 |
0.982 |
1.830 |
In conclusion the water solubility is apparently not dependent on temperature but slightly dependent on pH-value.
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 0.982 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined according to OECD 105 (1995) using a column elution method based on a preliminary test showing the water solubility lower than 10 mg/L. The test was performed under GLP. The concentrations were analyzed via GC-MS after reaching equilibration state. The water solubility of the test item was determined to be 0.982 mg/L at 20 °C and pH 7.0. The solubility of test item was determined in water at neutral pH (distilled water being in equilibrium with atmospheric carbon dioxide) at 10, 20 and 30 °C. It showed that the water solubility of the test item is not dependent on temperature, but slightly dependent on pH-value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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