Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
413-110-2
CAS no.:
-
Index number:
Molecular formula:
C24H30O6
SMILES:
CC1=CC=C(C=C1C)C1OCC2OC(OC(C(O)CO)C2O1)C1=CC=C(C)C(C)=C1
InChI:
InChI=1/C24H30O6/c1-13-5-7-17(9-15(13)3)23-27-12-20-22(30-23)21(19(26)11-25)29-24(28-20)18-8-6-14(2)16(4)10-18/h5-10,19-26H,11-12H2,1-4H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
17
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Breakdown of all 16 C&L notifications submitted to ECHA

Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 16 active registrations under REACH, 1 Joint Submission(s) and 14 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000+ tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: polymers.

Other release to the environment of this substance is likely to occur from: indoor use, outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, of substances in closed systems with minimal release and formulation in materials. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines), vehicles and electrical batteries and accumulators. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: polymers.

This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: transfer of substance into small containers, closed batch processing in synthesis or formulation, mixing in open batch processes, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, transfer of chemicals, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and of substances in closed systems with minimal release. Other release to the environment of this substance is likely to occur from: indoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following products: polymers.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, in the production of articles and of substances in closed systems with minimal release. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: polymers.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, mixing in open batch processes, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: in the production of articles, as processing aid, of substances in closed systems with minimal release, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ADEKA PALMAROLE SAS, 13 rue du 17 Novembre FR-68100 MULHOSE France
  • ADEKA POLYMER ADDITIVES EUROPE SAS, 13 rue du 17 Novembre FR-68100 MULHOUSE France
  • Borealis AG, Wagramerstrasse 17-19 1220 Wien Austria
  • Chemservice GmbH - (X88M), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • COVANCE CRS SA 098, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5-5 Planta 28050 Madrid Spain
  • Everspring Europe Sprl, Rue Rodenbach 125 1190 Brussels Belgium
  • Handelsvertretung Sabine Alisch, Fontaneweg 22 16547 Birkenwerder Germany
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Milliken Europe B.V.B.A. (OR), Ham 18-24 9000 Gent Belgium
  • REACH COMPLIANCE SERVICES LIMITED, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP (Zibo Rainwell Chemical Co., Ltd.), Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • RiKA International Limited, 3 Howarth Court, Gateway Crescent Broadway Business Park OL9 9XB Chadderton Oldham United Kingdom
  • TÜV SÜD Iberia, S.A.U. (068), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • [Confidential], [Confidential]
  • ROQUETTE Frères, 1 rue de la haute loge 62136 LESTREM Cedex France

Substance names and other identifiers

GEL ALL DX
REACH pre-registration
D-Glucitol, 1,3:2,4-bis-O-[(3,4-dimethylphenyl)methylene]-
Other
(1R)-1-((4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)ethane-1,2-diol
Registration dossier
(1R)-1-((4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxino-4-yl) ethane-1,2-diol
Registration dossier
(1R)-1-[(4R, 4aR, 8aS)-2,6-bis(3,4-dimethylphenyl)-4,4a, 8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
Registration dossier
(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxane[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
Registration dossier
(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
Registration dossier
1,3:2,4-Bis(3,4-dimethylbenzylidene) sorbitol
Registration dossier
1,3:2,4-bis-O-(3,4-dimethylbenzylidene)-D-glucitol
Registration dossier
1-[2,6-bis(3,4-dimethylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
Other
bis(3,4-dimethylbenzylidene) sorbitol
Registration dossier
Flyadd-3
Registration dossier
Flyclear-398
Registration dossier
T-1540N
Registration dossier
TOWREX NU700
Registration dossier
D-Glucitol, 1,3:2,4-bis-O-[(dimethylphenyl)methylene]-
Registration dossier
DISORBENE 3
Registration dossier
Everclear 3988
Registration dossier
EVERCLEAR 3988i
Registration dossier
EVERCLEAR3988
Registration dossier
EVERCLEAR3988S
Registration dossier
Everstab 3988
Registration dossier
Gell all DX
Registration dossier
K-CLEAR 34A
Registration dossier
K-CLEAR 34i
Registration dossier
K-CLEAR 34S
Registration dossier
K-CLEAR34
Registration dossier
Millad 3988
Registration dossier
1171816-77-5
Deleted CAS number
Other
1242238-46-5
Deleted CAS number
Other
135861-56-2
CAS number
Other
1581883-40-0
Deleted CAS number
Other
182077-81-2
Deleted CAS number
Other
475558-57-7
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 16 studies submitted
  • 13 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [13]
C Form
Powder (100%) [13]
C Odour
Odourless (43%), Other (43%), Slight (14%) [7]
C Substance type
Organic (100%) [10]

Type of Study provided
Studies with data
Key study 9 5
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 8 summaries submitted
  • 8 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 22 studies submitted
  • 12 studies processed
R Melting / freezing point
258.4 - 274.49 °C @ 101.3 - 102.12 kPa [15]

Type of Study provided
Studies with data
Key study 15
Supporting study 5
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 9 summaries submitted
  • 7 summaries processed
Melting / freezing point at 101 325 Pa
261 - 274 °C

Boiling point

Study results
  • 15 studies submitted
  • 13 studies processed
R Boiling point
262 - 399.85 °C @ 101.3 - 102.12 kPa [13]

Type of Study provided
Studies with data
Key study 14
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 9 summaries submitted
  • 4 summaries processed
Boiling point at 101 325 Pa
262 - 359.85 °C

Density

Study results
  • 25 studies submitted
  • 14 studies processed
R Density
1.235 g/cm³ @ 21 °C [1]
R Relative density
0.72 - 1.24 @ 20 - 22 °C [14]

Type of Study provided
Studies with data
Key study 17
Supporting study 6
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 7 summaries processed
Relative density at 20°C
0.72 - 1.24

Vapour pressure

Study results
  • 26 studies submitted
  • 13 studies processed
R Vapour pressure
0 - 0 Pa @ 25 °C [13]

Type of Study provided
Studies with data
Key study 16
Supporting study 8
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 9 summaries submitted
  • 8 summaries processed
Vapour pressure
0 - 0 Pa @ 25 °C

Partition coefficient

Study results
  • 27 studies submitted
  • 15 studies processed
R Log Pow
2.78 - 3.4 @ 22 - 30 °C and pH 7 [15]

Type of Study provided
Studies with data
Key study 18
Supporting study 6 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 9 summaries submitted
  • 8 summaries processed
Log Kow (Log Pow)
2.78 - 3.4 @ 22 - 30 °C

Water solubility

Study results
  • 25 studies submitted
  • 13 studies processed
R Water solubility (mass/vol.)
40 - 720 000 ng/L @ 20 - 22 °C and pH 5.8 - 8.5 [13]

Type of Study provided
Studies with data
Key study 16
Supporting study 7
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 9 summaries submitted
  • 8 summaries processed
Water solubility
40 - 47 600 ng/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 17 studies submitted
  • 10 studies processed
R Surface tension
72.2 - 72.4 mN/m @ 10 - 30 µg/L and 24.5 - 25 °C [12]

Type of Study provided
Studies with data
Key study 12
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 6 summaries submitted
  • 5 summaries processed
Surface tension at 20 °C
72.4 mN/m @ 0.03 mg/L

Flash point

Study results
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 6
Sci. unjustified 5
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 25 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
262 - 420 °C [5]

Type of Study provided
Studies with data
Key study 14
Supporting study 8
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 8 summaries submitted
  • 5 summaries processed
Autoflammability / self-ignition at 101 325 Pa
262 - 420 °C

Flammability

Study results
  • 32 studies submitted
  • 13 studies processed
C Interpretation of results
Non flammable (85%), GHS criteria not met (15%) [13]

Type of Study provided
Studies with data
Key study 23
Supporting study 7
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 10 summaries submitted
  • 9 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 16 studies submitted
  • 6 studies processed
C Interpretation of results
Non-explosive (100%) [6]

Type of Study provided
Studies with data
Key study 13
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 8 summaries submitted
  • 8 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 16 studies submitted
  • 1 study processed
C Interpretation of results
GHS criteria not met (100%) [1]

Type of Study provided
Studies with data
Key study 12
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 7 summaries submitted
  • 7 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
64.38 - 128.16 min [2]
R Degradation rate constant (OH radicals)
0 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
2.136 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 1
Sci. unjustified 6
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 38 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 17
Supporting study 18
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 9 summaries submitted
  • 6 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (83%), Inherently biodegradable (17%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
37

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 11 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 7 summaries processed
Koc at 20°C
2.96 - 1 620

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 10 summaries submitted
  • 9 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 50 - 3 000 ng/L (5)
Intermittent releases (freshwater) 400 - 1 000 ng/L (5)
Marine water 5 - 300 ng/L (5)
Intermittent releases (marine water) No data: aquatic toxicity unlikely (3)
Sewage treatment plant (STP) 10 - 100 mg/L (7)
Sediment (freshwater) 700 - 494 000 ng/kg sediment dw (5)
Sediment (marine water) 70 - 474 ng/kg sediment dw (4)
Hazard for Air
Air No hazard identified (9)
Hazard for Terrestrial Organism
Soil 800 - 10 000 000 ng/kg soil dw (5)
Hazard for Predators
Secondary poisoning 90 300 g/kg food (1)

Short–term toxicity to fish

Study results
  • 24 studies submitted
  • 15 studies processed
P/RResults
LC50 (4 days) 40 - 200 µg/L [15]
LC50 (72 h) 50 - 100 µg/L [12]
LC50 (48 h) 50 - 100 µg/L [12]
LC50 (24 h) 50 - 100 µg/L [12]
LC0 (3.2 months) 200 µg/L [1]

Type of Study provided
Studies with data
Key study 16 1
Supporting study 4 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 5 summaries processed
LC50 for freshwater fish
50 - 100 µg/L
LC50 for marine water fish
100 µg/L

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (33 days) 30 µg/L [1]
LOEC (33 days) 30 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 26 studies submitted
  • 16 studies processed
P/RResults
EC50 (48 h) 40 - 100 µg/L [16]
EC50 (24 h) 50 - 100 µg/L [15]
EC100 (48 h) 100 µg/L [5]
NOEC (48 h) 50 - 100 µg/L [15]
NOEC (24 h) 100 µg/L [1]

Type of Study provided
Studies with data
Key study 19
Supporting study 5
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 5 summaries processed
EC50 / LC50 for freshwater invertebrates
50 - 100 µg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 48 µg/L [1]
LOEC (21 days) 48 µg/L [1]
EC50 (21 days) 48 µg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 16 studies submitted
  • 13 studies processed
P/RResults
EC50 (72 h) 18 - 120 µg/L [16]
NOEC (72 h) 40 - 100 µg/L [19]

Type of Study provided
Studies with data
Key study 14
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
EC50 for freshwater algae
18 - 100 µg/L
EC10 or NOEC for freshwater algae
80 - 120 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 14 studies submitted
  • 10 studies processed
P/RResults
EC50 (3 h) 47.6 - 1 000 000 µg/L [3]
EC50 (30 min) 1 g/L [1]
IC50 (3 h) 1 g/L [8]
NOEC (3 h) 100 - 1 000 mg/L [9]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 6 summaries submitted
  • 6 summaries processed
EC50 for microorganisms
1 g/L
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (14 days) 1 g/kg soil dw [1]
LC50 (14 days) 1 g/kg soil dw [2]
LC50 (7 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 1 g/kg soil dw [3]
EC50 (21 days) 1 g/kg soil dw [6]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 9 summaries submitted
  • 9 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11.75 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 14.33 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 14.33 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 14.33 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.33 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 400 mg/kg bw/day acute toxicity
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.89 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 3.534 mg/m³ acute toxicity
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: (DNEL) 3.534 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.66 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 200 mg/kg bw/day acute toxicity
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.66 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 3.032 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 8 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 29 studies submitted
  • 16 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [7]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 19
Supporting study 8
Weight of evidence
Other 2
Data waiving
no waivers
inhalation
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 7
dermal
  • 22 studies submitted
  • 13 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [8]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study 13
Supporting study 5
Weight of evidence 2
Other 2
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 9 summaries submitted
  • 7 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 19
Supporting study 8
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 20
Supporting study 7
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 9 summaries submitted
  • 9 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 21
Supporting study 6
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 9 summaries submitted
  • 9 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 20 studies submitted
  • 9 studies processed
P/RResults
NOAEL (rat): 406.4 - 1 000 mg/kg bw/day [10]
NOEL (rat): 123.1 - 200 mg/kg bw/day [10]

Type of Study provided
Study data: oral
Studies with data
Key study 16
Supporting study 1 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
M/C Summaries
  • 9 summaries submitted
  • 9 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 406 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 115 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 43
Supporting study 31 6
Weight of evidence 14
Other 3 18
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 10 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 3
Other 4
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant