Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

No image available
EC / List no.:
265-198-5
CAS no.:
64742-94-5
Index number:
649-424-00-3
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
42
Of which contain:
5 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may be fatal if swallowed and enters airways.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is fatal if inhaled, is very toxic to aquatic life with long lasting effects, is very toxic to aquatic life, may cause cancer, is a highly flammable liquid and vapour, causes serious eye irritation, is suspected of causing cancer, may cause damage to organs, is suspected of damaging fertility or the unborn child, is harmful if swallowed, is harmful in contact with skin, is suspected of causing genetic defects, causes skin irritation, may cause drowsiness or dizziness, may cause respiratory irritation and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects and is a flammable liquid and vapour.

Breakdown of all 4054 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Aquatic Chronic 2 H411
Flam. Liq. 3 H226
Eye Irrit. 2 H319
STOT SE 3 H336
Skin Irrit. 2 H315
Carc. 2 H351
STOT SE 3 H335
Carc. 1B H350
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
Repr. 2 H361
Skin Sens. 1B H317
STOT RE 2 H373
Flam. Liq. 2 H225
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (13.02% of REACH registrations).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (2.79% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 24 active registrations under REACH, 5 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, adhesives and sealants, polishes and waxes, fuels, coating products and anti-freeze products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, non-industrial spraying, roller or brushing applications and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: fuels, coating products, fillers, putties, plasters, modelling clay, inks and toners, polymers and oil and gas exploration or production products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, inks and toners and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: of substances in closed systems with minimal release, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, as processing aid and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, laboratory work, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and as processing aid.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Keep out of reach of children.

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; do not handle until all safety precautions have been read and understood; do not breathe the dust, fume, gas, mist, vapours or spray; take actions to prevent static discharges; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Get medical advice/attention if you feel unwell. If skin irritation occurs: Get medical advice/attention. Do not induce vomiting. Collect spillage. If on skin: wash with soap and water. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Caplinq Europe B.V., Industrieweg 15E 1566JN Assendelft - Netherlands
  • Chematek s.p.a., Piazzale Libia, 1 20135 Milano Lombardia Italy
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Standards SIA, Ritausma 31 LV-2127 Medemciems Olaine parish Latvia
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • CS Regulatory IRL Ltd 2M-6, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • Dow Belgium B.V.B.A., Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • Ekobenz Sp. z o.o., ul. Zimna 11 20-204 Lublin Poland
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • L' ARCA S.r.l., via s.andrea 38/b 56029 Santa Croce Sull'Arno PISA Italy
  • Milliken Europe B.V., Ham 18-24 9000 Gent Belgium
  • Nouryon Surface Chemistry AB, Box 47067 40258 Göteborg Sweden
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • Rout Bréck Consulting S. à r. l. (Silachem), 77, rue du canal, L-4051 Esch-Sur-Alzette, Luxembourg
  • Shell Deutschland GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany
  • TÜV SÜD Iberia S.A.U. (008), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Spain
  • TÜV SÜD Iberia S.A.U. (033), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Industrie Service GmbH (28), Westendstrasse 199 80686 Munich Germany
  • TÜV SÜD Industrie Service GmbH (32), Westendstrasse 199 80686 Munich Germany
  • UAB "Mida LT", Gamyklos st. 19 LT-96155 Gargzdai Klaipedos distr. Lithuania
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CRAY VALLEY SA, 2 Place Jean Millier 92400 Courbevoie France
  • DOW CHEMICAL COMPANY LTD, Diamond House, Lotus Park Kingsbury Crescent Middx UB7 0DQ Staines Middx United Kingdom
  • ExxonMobil Petroleum & Chemical BV, Polderdijkweg 2030 Antwerpen Belgium
  • Haltermann Carless UK Limited, Grove House Guildford Road KT22 9DF Leatherhead Surrey United Kingdom
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Rain Carbon Germany GmbH, Kekulestr. 30 44579 Castrop-Rauxel Germany
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • SABIC UK Petrochemicals Limited, Wilton Centre TS10 4RF Redcar Cleveland United Kingdom
  • SARPOM S.r.l., Viale Castello della Magliana 25 00148 Roma Italy
  • TotalEnergies Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium
  • UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany

Substance names and other identifiers

(Polyethyl)benzenes
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
Heavy aromatic naphtha
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
Heavy aromatic solvent naphtha (petroleum)
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
High-flash aromatic naphtha
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
Shellsol R
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
Solvent naphtha (petroleum), heavy arom.
EC Inventory, Other
Solvent naphtha (petroleum), heavy arom.
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
REACH pre-registration, Other
Solvent naphtha (petroleum), heavy arom.; Kerosine — unspecified [ complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 °C to 290 °C (330 °F to 554 °F).]
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances
Solvent naphtha (petroleum), heavy arom.; Kerosine — unspecified [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 °C to 290 °C (330 °F to 554 °F).]
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
Solvent naphtha
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
Solvent naphtha, petroleum, heavy arom.
A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Other
Liuotinbensiini (maaöljy), raskas aromaattinen Kerosiini - täsmentämätön (fi)
C&L Inventory
Solvent nafta (petrol), aromatice grele; kerosenului. - Nespecificat [O combinaţie complexă de hidrocarburi, obţinuta din distilare de fluxuri aromatice. Se compune în principal din hidrocarburi aromatice cu număr de atomi de carbon predominant în intervalul C9 la C16 şi interval de fierbere aproximativ de la 165 ° C la 290 ° C (330 la 554 de).] (ro)
C&L Inventory
solvent-nafta (nafta), težka aromatska Kompleksna kombinacija ogljikovodikov dobljena z destilacijoaromatskih iztokov. Sestoji pretežno iz aromatskihogljikovodikov, ki imajo število ogljikov pretežnov območju od C9 do C16 in vrelišče v območju od približno 165° C do 290° C (330° F do 554° F). (sl)
C&L Inventory
solventnafta (nafta) sunkioji, aromatinė žibalas-detaliau nenurodyta [sudėtingas angliavandenilių mišinys, gaunamas distiliuojant aromatinius srautus. Jame vyrauja aromatiniai angliavandeniliai kurių vyraujantis anglies atomų skaičius yra tarp C9 ir C15, verdantys apytiksliai tarp 165°C ir 290°C (330°F ir 554°F) temperatūroje.] (lt)
C&L Inventory
solventnafta (petroleum), tung aromatisk aromatnafta, tung lacknafta, tung aromatisk (sv)
C&L Inventory
Szolvens nafta (ásványolaj), erősen aromas [Aromás kőolaj frakciók desztillátuma. C9-C16 szénatomszámú aromás szénhidrogének keveréke. Forráspont tartomány: 165 C° - 290 C° (330 °F - 554 °F).] (hu)
C&L Inventory
Δδιαλύτης νάφθα (πετρελαίου), βαρεία αρωματική Κηροζίνη - μη προδιαγεγραμμένη (el)
C&L Inventory
(EZ)-(RS)-2-{1-[(2E)-3-chloroallyloxyimino]propyl}-3-hydroxy-5-perhydropyran-4-ylcyclohex-2-en-1-one
C&L Inventory
[A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range
C&L Inventory
[A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range ...
C&L Inventory
aromatic hydrocarbons C9-C12
C&L Inventory
aromatic naphta solvent
C&L Inventory
C9-oil
Registration dossier
Heavy aromatic solvent naphtha (Petroleum)
C&L Inventory
Kerosine
Registration dossier
n/av
C&L Inventory
naphta, heavy aromatic
C&L Inventory
Naphtha (petroleum), heavy aromatic
C&L Inventory
NAPHTHA, PETROLEUM, HEAVY AROMATIC
C&L Inventory
Not applicable for a UVCB
C&L Inventory
not available
C&L Inventory
petroleum product
C&L Inventory
Reaction mass of 108-67-8 and 91-20-3 and 95-63-6
C&L Inventory
solvant naphta lourds
C&L Inventory
Solvent
C&L Inventory
Solvent Naphta
C&L Inventory
Solvent naphta (petroleum), heavy arom
Registration dossier
Solvent naphta (petroleum), heavy arom.
C&L Inventory
Solvent naphta (petroleum), heavy aromatic
C&L Inventory
solvent naphta heavy aromatic
C&L Inventory
Solvent naphtha
C&L Inventory
Solvent Naphtha
C&L Inventory, Registration dossier
Solvent naphtha (petroleum)
C&L Inventory
Solvent naphtha (petroleum), heavy arom
C&L Inventory
Solvent naphtha (petroleum), heavy arom
Registration dossier
Solvent naphtha (petroleum), heavy arom.
C&L Inventory, Registration dossier
Solvent naphtha (petroleum), heavy arom.
C&L Inventory, Registration dossier
Solvent naphtha (petroleum), heavy arom. (C>5% aromatics)
C&L Inventory
SOLVENT NAPHTHA (PETROLEUM), HEAVY AROM. (R66-67)
C&L Inventory
Solvent naphtha (petroleum), heavy arom. Kerosine — unspecified; [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC (330oF to 554oF).]
C&L Inventory
Solvent naphtha (petroleum), heavy arom.# Kerosine - unspecified
C&L Inventory
Solvent naphtha (petroleum), heavy arom.;
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; Kerosine
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified;
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; Kerosine - unspecified[A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC (330 oF to 554 oF).]
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; Kerosine — unspecified; [A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165 oC to 290 oC (330oF to 554oF).]
C&L Inventory
Solvent naphtha (petroleum), heavy arom.; kerosine-unspecified
C&L Inventory
SOLVENT NAPHTHA (PETROLEUM), HEAVY AROMATIC
C&L Inventory, Registration dossier
Solvent naphtha (petroleum), heavy aromomatic
C&L Inventory
solvent naphtha (petroleum), highly arom.
C&L Inventory
Solvent naphtha heavy aromatic
C&L Inventory
Solvent naphtha petroleum, heavy aromatic
C&L Inventory
Solvent naphtha(petroleum), heavy arom.
C&L Inventory
Solvent naphtha, heavy, arom.
Registration dossier
Solvent naphtha, petroleum, heavy arom.
C&L Inventory
Solvent naptha (petroleum), heavy arom.
C&L Inventory
solventní nafta (ropná), těžká aromatická
C&L Inventory
UVCB substance
C&L Inventory
Fioul retour
Registration dossier
huile fluxante
Registration dossier
Novasolve
Registration dossier
Petrinex T9
Registration dossier
Residu HEN
Registration dossier
SOLVESSO 150 ND
C&L Inventory
UNIAROM(R) TX 200ND DA
Registration dossier
64742-94-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
649-424-00-3
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 36 studies submitted
  • 36 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (97%) [36]
C Form
Other (60%), Viscous (25%), Not specified (10%) [20]
C Odour
Characteristic of aromatic compounds (59%), Other (30%), Pungent (7%) [27]
C Substance type
Petroleum product (59%), Organic (38%) [29]

Type of Study provided
Studies with data
Key study 30 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 15 studies submitted
  • 12 studies processed
R Melting / freezing point
-100 - 53 °C @ 101.3 - 101.325 kPa [13]

Type of Study provided
Studies with data
Key study 13
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Melting / freezing point at 101 325 Pa
-95.15 - 32.2 °C

Boiling point

Study results
  • 34 studies submitted
  • 28 studies processed
R Boiling point
25 - 421.5 °C @ 99.2 - 101.325 kPa [29]

Type of Study provided
Studies with data
Key study 30 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Boiling point at 101 325 Pa
110.85 - 172.2 °C

Density

Study results
  • 21 studies submitted
  • 11 studies processed
R Bulk density
0.77 - 0.85 g/cm³ @ 15 °C [1]
R Density
0.77 - 0.85 g/cm³ @ 15 °C [1]
R Relative density
0.69 - 1.11 @ 15.556 - 20 °C [9]

Type of Study provided
Studies with data
Key study 19
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Relative density at 20°C
0.911 - 866

Vapour pressure

Study results
  • 37 studies submitted
  • 27 studies processed
R Vapour pressure
71 - 58 484 Pa @ 19.9 - 100 °C [34]

Type of Study provided
Studies with data
Key study 35
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Vapour pressure
1.86 - 30.89 hPa @ 20 - 21.1 °C

Partition coefficient

Study results
  • 13 studies submitted
  • 9 studies processed
R Log Pow
2.4 - 6.5 @ 21 - 25 °C and pH 6.2 - 7 [9]

Type of Study provided
Studies with data
Key study 10 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
2.73 - 6.5 @ 20 °C

Water solubility

Study results
  • 13 studies submitted
  • 5 studies processed
R Water solubility (mass/vol.)
33 - 108 mg/L @ 20 °C and pH 6.4 - 7.3 [5]

Type of Study provided
Studies with data
Key study 7 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 8 summaries submitted
  • 3 summaries processed
Water solubility
20 - 587 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
R Summaries
  • 5 summaries submitted
  • 1 summary processed
Surface tension at 20 °C
71.8 mN/m @ 244 mg/L

Flash point

Study results
  • 23 studies submitted
  • 21 studies processed
R Flash point
-30 - 145 °C @ 100.6 - 101.325 kPa [22]

Type of Study provided
Studies with data
Key study 21
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
73 °C

Auto flammability

Study results
  • 11 studies submitted
  • 9 studies processed
R Autoflammability / self-ignition
220 - 505 °C @ 99.5 - 101.325 kPa [9]

Type of Study provided
Studies with data
Key study 9
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
421 °C

Flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 3
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 5
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 3
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 21 studies submitted
  • 17 studies processed
R Other:
1 - 29 [8]
R dynamic viscosity (in mPa s)
0.32 - 1 330 [11]
R kinematic viscosity (in mm²/s)
0.47 - 1 220 [17]

Type of Study provided
Studies with data
Key study 17
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Static viscosity at 20 °C
3.25 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 4
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 16 studies submitted
  • 3 studies processed
C Interpretation of results
Inherently biodegradable (33%), Not readily biodegradable (33%), Under test conditions no biodegradation observed (33%) [3]

Type of Study provided
Studies with data
Key study 7 2
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 6 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 6 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
150.1 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 5 summaries submitted
  • 1 summary processed
Koc at 20°C
3.04

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 91.57 % [1]
R Water 1.54 % [1]
R Soil 4.82 % [1]
R Sediment 2.07 % [1]
R Suspended sediment 0.1 % [1]
R Biota 0.1 % [1]
R Aerosol 0.1 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 6 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (2)
Intermittent releases (freshwater) No data available: testing technically not feasible (2)
Marine water No data available: testing technically not feasible (2)
Intermittent releases (marine water) No data available: testing technically not feasible (2)
Sewage treatment plant (STP) No data available: testing technically not feasible (2)
Sediment (freshwater) No data available: testing technically not feasible (2)
Sediment (marine water) No data available: testing technically not feasible (2)
Hazard for Air
Air Hazard related to composition of atmosphere identified (1)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 27 studies submitted
  • 13 studies processed
P/RResults
LC50 (4 days) 580 - 8 410 µg/L [5]
NOEC (4 days) 5.6 mg/L [1]
LL50 (4 days) 730 - 48 000 µg/L [12]
LL50 (72 h) 2 - 5 mg/L [2]
LL50 (48 h) 2 - 54.4 mg/L [4]

Type of Study provided
Studies with data
Key study 12 1
Supporting study 12
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 6 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 25 studies submitted
  • 12 studies processed
P/RResults
EC50 (48 h) 760 - 4 700 µg/L [6]
EC50 (24 h) 1.4 mg/L [1]
LL50 (48 h) 1.99 mg/L [1]
EL50 (48 h) 910 - 13 000 µg/L [9]
EL50 (24 h) 1.6 - 9.83 mg/L [4]

Type of Study provided
Studies with data
Key study 11 1
Supporting study 12
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 6 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EL50 (21 days) 810 - 890 µg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 21 studies submitted
  • 8 studies processed
P/RResults
EC50 (4 days) 11.7 - 18.4 mg/L [2]
EC50 (72 h) 12.4 - 18.9 mg/L [2]
NOEC (4 days) 120 - 7 840 µg/L [4]
NOEC (72 h) 300 - 6 470 µg/L [4]
EL50 (72 h) 790 - 8 950 µg/L [5]

Type of Study provided
Studies with data
Key study 10 1
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
790 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 470 mg/L [1]
NOEC (5 days) 2 mg/L [1]
EC10 (3 h) 220 mg/L [1]

Type of Study provided
Studies with data
Key study 2 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 6 summaries submitted
  • 1 summary processed
EC50 for microorganisms
28.99 mg/L

Sediment toxicity

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 10
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 10
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 10
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 8 summaries submitted
  • 7 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.31 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 384 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 2.31 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 160.23 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 950 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 690 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 226 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 690 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 143.5 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 280 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 30 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 25.6 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 6 4
Weight of evidence
Other 2 3
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal absorption
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 3 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
M/C Summaries
  • 7 summaries submitted
  • 4 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 3.6 %
Inhalation: 50 %

Acute toxicity

Study results
oral
  • 39 studies submitted
  • 15 studies processed
P/RResults
LD50 2 000 - 6 631 mg/kg bw (rat) [15]
LD50 5 251 - 5 627 mg/kg bw (mouse) [2]
M/CInterpretations of results
Not classified [10]

Type of Study provided
oral
Studies with data
Key study 14 1
Supporting study 13 11
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 43 studies submitted
  • 16 studies processed
P/RResults
LC50 (7 h) 1.6 - 1.86 mg/L air (rat) [2]
LC50 (4 h) 2.7 - 30 000 mg/m³ air (rat) [20]
LC50 (4 h) 5 922 - 6 700 ppm (rat) [5]
M/CInterpretations of results
Not classified [11]

inhalation
Studies with data
Key study 12 4
Supporting study 13 14
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 35 studies submitted
  • 14 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [3]
LD50 2 000 - 12 126 mg/kg bw (rabbit) [10]
LD50 5 000 mL/kg bw (rabbit) [1]
M/CInterpretations of results
Not classified [10]

dermal
Studies with data
Key study 12 1
Supporting study 10 11
Weight of evidence 1
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 4 summaries processed
Oral route:
Adverse effect observed LD50 590 mg/kg bw
Inhalation route:
Adverse effect observed LC50 1.972 mg/L air
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 55 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 15 6
Supporting study 13 17
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 46 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 13 1
Supporting study 11 16
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 8 summaries submitted
  • 7 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 8 1
Supporting study 9 13
Weight of evidence 1
Other 3
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 7 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 23 studies submitted
  • 15 studies processed
P/RResults
NOAEL (rat): 5 - 750 mg/kg bw/day [18]
NOAEL (mouse): 625 mg/kg bw/day [1]
LOAEL (rat): 25 - 1 250 mg/kg bw/day [9]
LOAEL (mouse): 1 250 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 9 6
Supporting study 1 3
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 26 studies submitted
  • 19 studies processed
P/RResults
NOAEL (rat): 1 mg/L air [2]
NOAEL (mouse): 1 mg/L air [1]
LOAEL (rat): 500 mg/m³ air [2]
NOAEC (rat): 24 - 2 355 mg/m³ air [11]
NOAEC (rat): 30 - 1 800 ppm [17]

Study data: inhalation
Studies with data
Key study 10 9
Supporting study 4
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 34 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 495 mg/kg bw/day [1]
LOEL (rat): 165 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1 1
Supporting study 8 15
Weight of evidence
Other 5
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
M/C Summaries
  • 8 summaries submitted
  • 4 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 4 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 495 mg/kg bw/day (subchronic, rat)
Dermal route - local effects:
Adverse effect observed LOAEL 1 mg/cm² (subchronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 1 000 mg/m³ (subchronic, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 1 000 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 45 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 21 9
Supporting study 4 8
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 15 5
Supporting study 1 9
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 3 summaries processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 12 7
Supporting study 4 6
Weight of evidence
Other 7
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 8 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 4 522 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 7 1
Supporting study 4 4
Weight of evidence 2
Other 3
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Study data: developmental
  • 29 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 11 4
Supporting study 2 3
Weight of evidence 3
Other 5
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 8 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 60 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 1 000 mg/m³ (subacute, rat)

Immunotoxicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Dermal route:
No adverse effect observed NOAEL 495 mg/kg bw/day (subacute, rat)

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant