Registration Dossier
Registration Dossier
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EC number: 204-493-5 | CAS number: 121-69-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data taken from CESARS
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- CESARS Record no.:209
- Year:
- 2 011
- Bibliographic source:
- CESARS (Chemical Evaluation Search and Retrieval System ); Kiese, M. and G. Renner. 1974. Urinary metabolites of N,N-dimethylaniline produced by dogs. Naunyn-Schmeideberg's Arch.Pharmacol. 283(2)143-50. From CAS:81:86484.
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Study obtained from CESARS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N-dimethylaniline
- EC Number:
- 204-493-5
- EC Name:
- N,N-dimethylaniline
- Cas Number:
- 121-69-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- N,N-dimethylaniline
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: injected
- Vehicle:
- unchanged (no vehicle)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40 mg/kg
- Control animals:
- not specified
- Details on study design:
- A dose of 40 mg/kg N,N-dimethylaniline was injected into dogs and the urine was analyzed for metabolites.
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- N,N-dimethylaniline was injected into dogs and the urine was analyzed for metabolites.
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- The metabolites 4-aminophenol, 4-(methylamino)phenol, 4- (dimethylamino)phenol, 2-aminophenol and N-methylaniline were isolated as crystalline hydrochlorides and 2- (dimethylamino)phenol in very small amounts. Aniline was not found in the urine. Nearly 2E-5 M aniline was found in the blood after the injection.
Applicant's summary and conclusion
- Conclusions:
- Aniline was not found in the urine. Nearly 0.00002 M aniline was found in the blood after the injection.
- Executive summary:
A dose of 40 mg/kg N,N-dimethylaniline was injected into dogs and the urine was analyzed for metabolites. The metabolites 4-aminophenol, 4-(methylamino)phenol, 4- (dimethylamino)phenol, 2-aminophenol and N-methylaniline were isolated as crystalline hydrochlorides and 2- (dimethylamino)phenol in very small amounts. Aniline was not found in the urine. Nearly 2E-5 M aniline was found in the blood after the injection.
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