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EC number: 203-455-5 | CAS number: 107-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-01-06 to 1981-02-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- This study is classified as reliable with restrictions because it was conducted in accordance to GLP and was reviewed by Quality Assurance. There were no deviations from protocol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: UBTL test protocol NO. 02-50
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Propane-1-thiol
- EC Number:
- 203-455-5
- EC Name:
- Propane-1-thiol
- Cas Number:
- 107-03-9
- Molecular formula:
- C3H8S
- IUPAC Name:
- propane-1-thiol
- Details on test material:
- - Name of test material (as cited in study report): propane-1-thiol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: University of Utah vivarium
- Housing: housed individually in galvanized steel rabbit cage with screen floors and pans
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 3
- Humidity (%): 30 to 60
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 6 New Zealand albino rabbits
- Details on study design:
- TEST SITE
- Type of wrap if used: gauze patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lightly sponged
-Test substance was removed after 24 hours
- Time after start of exposure: 7 days
SCORING SYSTEM: Draize technique
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No score reported at 48 hours.
- Irritant / corrosive response data:
- Three of six animals treated with propane-1-thiol sample exhibited very slight erythema on both abraded and unabraded sites at 25 hours post dosing. The other 3 animals appeared normal. Animals were not scored for irritatation at 48 hours after dosing. At 72 hours post dosing, 1 animal had very slight erythema on the abraded site only. All other animals had either returned to normal or remained normal. On day 7, no erythema and/or oedema was observed in any animal.
Any other information on results incl. tables
Animal Number |
627 |
628 |
646 |
614 |
615 |
616 |
Ave. |
Range |
Observation, prescreen |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
25 hour |
1 |
0 |
0 |
0 |
1 |
1 |
0.5 |
0-1 |
72 hour |
0 |
0 |
0 |
0 |
0.5 |
0 |
0.1 |
0-0.5 |
7 day |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Combined 25 & 72 hour |
0.5 |
0 |
0 |
0 |
0.8 |
0.5 |
0.3 |
0-0.8 |
Combined 25 & 72 hour and 7 day |
0.3 |
0 |
0 |
0 |
0.5 |
0.3 |
0.2 |
0-0.5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Propane-1-thiol was slightly irritating to 3 out of 6 rabbits. Results were scored at 25 and 72 hrs and 7 days post exposure using the Primary Skin Irritation Test. The mean Draize score of 0.2 was tabulated from the 6 rabbits at these 3 observation periods.
- Executive summary:
In a primary dermal irritation study, intact and abraded skin of 6 young adult New Zealand albino rabbits was exposed to 0.5 mL of propane-1 -thiol for 24 hours to 1 square inch of abraded skin. Animals were then observed for 7 days. Irritation was scored by the method of Draize primary skin irritation test.
Propane-1-thiol was slightly irritating to 3 out of 6 rabbits; slight erythema was reported on both abraded and intact sites in 3 animals at 25 hours post dosing. The other 3 animals appeared normal. At 72 hours after dosing, 1 animal had slight erythema on the abraded site only. All other animals had either returned to normal or remained normal. On day 7, erythema and/or oedema was not observed in any animal. In this study, propane-1 -thiol is slightly irritating to the skin based on the Draize primary skin irritation test.
This study received a Klimisch score of 1 and is classified as reliable with restrictions because it was conducted in accordance to GLP and was reviewed by Quality Assurance. There were no deviations from protocol.
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