Propane-1-thiol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1976-09-23

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

Rabbits were observed for 7 days, not 14. No details on necropsy or observations of gross pathological changes were provided in the report.

GLP compliance:

not specified

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Propane-1-thiol

EC Number:

203-455-5

EC Name:

Propane-1-thiol

Cas Number:

107-03-9

Molecular formula:

C3H8S

IUPAC Name:

propane-1-thiol

Details on test material:

- Name of test material (as cited in study report): propane-1-thiol

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml/kg
TEST SITE
- Area of exposure: hair-clipped skin of the trunk
- Type of wrap if used: occluding sleeve


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg

Duration of exposure:

24 hours

Doses:

one

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

>= 2 000 mg/kg bw

Mortality:

No animals were reported to have died during the study

Clinical signs:

other: other: Initial skin contact evoked pain in every instance. When exposures were terminated, the skin of the entire trunk was gray mottled. It then became dry and thick which resulted in corrugational folding within four days. Subsequently, bleeding cracks

Gross pathology:

No data given

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

This study reported no toxic effects in rabbits exposed dermally to propane-1-thiol.

Executive summary:

In an acute dermal toxicity study, 6 young adult New Zealand albino rabbits were dermally exposed to propane-1-thiol for 24 hours at doses of 2,000 mg/kg bw. Animals were then observed for 7 days.

 

Initial skin contact evoked pain in every instance. When exposures were terminated, the skin of the entire trunk was gray mottled. It then became dry and thick which resulted in corrugational folding within four days. Subsequently, bleeding cracks appeared and surface exfoliation began. No animals died in the study; therefore the Dermal LD₅₀ for n-propyl mercaptan is greater than 2,000 mg/kg in rabbits.

 

This study received a Klimisch score of 4 and is classified as not assignable because there is very limited information in the report on the protocol and results. It was also carried out prior to GLP. This study may influence the DNEL.