Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 442-300-8
CAS number: -
Assessment of the toxicokinetic
No studies are available investigating
the toxicokinetic properties of the test substance.
The test substance is a liquid
consisting of a monoester and a diester compound with a molecular weight
of 370 (diester) and 238 (monoester). The water solubility is 0.0251 g/L
(di-substituted component) and 6.93 g/L (mono-substituted component),
the log Pow is 0.572 (monoester) and 3.01 (diester).
Based on the physico-chemical
properties (water solubility, molecular size, Log Pow) and in
consideration of Lipinski’s rule of Five, the test article is expected
to be absorbed during gastrointestinal passage. Absorption through the
skin is also anticipated. This is in line with the results obtained in a
guinea pig maximization study (Safepharm, 2002). Here, the test
substance caused sensitization upon skin contact demonstrating
penetration through the dermal barrier. No inhalation toxicity data are
available but physico-chemical properties indicate that inhalative
exposure might only be possible through aerosol aspiration.
Metabolism and Excretion
Upon oral administration, the test
item might be subject to cleavage to some extent in the
gastro-intestinal tract. A proportion might also be absorbed unchanged
and is subject to hepatic metabolic degradation. The test article is
readily biodegradable and subject to hydrolysis. It is not
bioaccumulating as shown experimentally. Hydrolysis reactions of the
esters may generate carboxylic acids and/or alcohols followed by
glucuronidation of the hydroxyl-groups. Subsequently, the test item
and/or its metabolites will be excreted effectively. The primary
elimination pathway might be the urinary excretion of parent compound
and the metabolites. In the available genotoxicity studies no
indications were found for the generation of toxic metabolites by
enzymatic reactions. Furthermore, by-products are identified and
qualified in the various experiments performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again