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Diss Factsheets
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EC number: 203-597-8 | CAS number: 108-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Metabolism of Malonic acid in Rat Brain after Intracerebral Injection.
- Author:
- Koeppen AH, Mitzen EJ, Papandrea JD
- Year:
- 1 978
- Bibliographic source:
- Journal of Neurochemistry 31 (3), 739-745.
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 20 (Malonic Acid Diesters: Dimethylmalonate, 108-59-8; Diethylmalonate, 105-53-3), April 19-22, 2005 Paris.
- Author:
- OECD SIDS
- Year:
- 2 005
- Bibliographic source:
- UNEP Publications
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Intracerebral injection of either C1- or C2- 14C- radiolabeled malonic acid to anesthetized adult male and female rats. The rats were killed after 2, 5, 10, 15 or 30 min and the brains removed, weighed, homogenized and analysed for radiolabeled reaction products. Venous blood and expired air was also analysed for radioactivity.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Malonic acid
- EC Number:
- 205-503-0
- EC Name:
- Malonic acid
- Cas Number:
- 141-82-2
- IUPAC Name:
- malonic acid
- Details on test material:
- C1 or C2 14-C-radiolabeled malonic acid, specific acitivity 12 mCi and 42 mCi respectively.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C1 or C2 14-C-radiolabeled malonic acid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: intracerebral
- Vehicle:
- not specified
- Details on exposure:
- Intracerebral injection of either C1- or C2- 14C- radiolabeled malonic acid to anesthetized adult male and female rats. The rats were killed after 2, 5, 10, 15 or 30 min and the brains removed, weighed, homogenized and analysed for radiolabeled reaction products. Venous blood and expired air was also analysed for radioactivity.
- Duration and frequency of treatment / exposure:
- single injection
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 µl (equivalent to 0.5 mCi)
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The authors verified that the decarboxylation of malonic acid to acetyl-CoA by various mammalian tissues also occurs in vivo after intracerebral injection. A rapid reflux of unreacted malonic acid in venous blood was reported. Labeled 14CO2 was recovered from venous blood and the expired air after administration of C-1 labeled product, but not after C-2 labeled product. High radioactivity was present in glutamate, aspartate and GABA. Sequential degradation of glutamate and aspartate proved that labeling of these amino acids occurred from [1-14C]acetyl-CoA and [2-14C]acetyl-CoA respectively via the Krebs-cycle. Malonate
activation and decarboxylation were similar to in vitro experiments with isolated mitochondria from different tissues. In vitro the radiolabel was however not incorporated into amino acids. In the in vivo experiment a minor amount of radioactivity was also incorporated in brain lipids. The authors conclude that malonic acid is metabolised via the following route:
Malonate + CoASH + ATP <---> malonyl-CoA + ADP + Pi
Malonyl-CoA --- > Acetyl-CoA + CO2
In vitro:
Acetyl-CoA --- > acetate + CoASH
In vivo: Acetyl-CoA enters the Krebs cycle and is used for the formation of aspartate, glutamate and GABA. A minor amount may also be incroporated into lipids.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.