Registration Dossier
Registration Dossier
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EC number: 203-597-8 | CAS number: 108-59-8
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from SIAR (no raw data available, original data result from well documented scientific reference)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Malonic Acid Diesters: Dimethylmalonate, 108-59-8; Diethylmalonate, 105-53-3.
- Author:
- OECD
- Year:
- 2 005
- Bibliographic source:
- SIDS Initial Assessment Report For SIAM 20
- Reference Type:
- publication
- Title:
- The identification of contact allergens by human assay.
- Author:
- Kligman, AM
- Year:
- 1 966
- Bibliographic source:
- J. Invest. Derm. 47, 393-409
- Reference Type:
- publication
- Title:
- Report to RIFM, 11th may
- Author:
- Kligman, AM
- Year:
- 1 976
- Bibliographic source:
- cited in: Opdyke DLJ (1979), Food Cosmet. Toxicol. 17, 363.
- Reference Type:
- publication
- Title:
- Updating the maximization test for identifying contact allergens.
- Author:
- Kligman, Am and Epstein, W
- Year:
- 1 975
- Bibliographic source:
- Contact Dermatitis 1, 231-239.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Maximization Test According to Kligman, 1966 and Kligman and Eppstein, 1975.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl malonate
- EC Number:
- 203-597-8
- EC Name:
- Dimethyl malonate
- Cas Number:
- 108-59-8
- Molecular formula:
- C5H8O4
- IUPAC Name:
- dimethyl malonate
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25
- Sex: no data
- Age: no data
- Race: no data
- Demographic information: no data - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: maximization test
ADMINISTRATION
- Vehicle / solvent: petrolatum
- Concentrations: 8%
Results and discussion
- Results of examinations:
- Tested at a concentration of 8 % in petrolatum, dimethylmalonate produced no sensitization in the maximization test in human subjects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
