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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(phenylmethoxy)naphthalene
EC Number:
405-490-3
EC Name:
2-(phenylmethoxy)naphthalene
Cas Number:
613-62-7
Molecular formula:
C17H14O
IUPAC Name:
2-(benzyloxy)naphthalene
Details on test material:
Powder

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Amount / concentration applied:
100 mg
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other: Overall at 24,48 and 72h
Score:
0.66
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other: overall at 24,28 and 72h
Score:
0
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other: overall at 24,48 and 72h
Score:
0
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: overall at 24,48 and 72h
Score:
1
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: overall at 24,48 and 72h
Score:
0
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other: overall at 24,48 and 72h
Score:
0.33
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other: overall at 24,48 and 72h
Score:
1.6
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: overall at 24,48 and 72h
Score:
0.66
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
other: overall at 24,48 and 72h
Score:
0.66
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other: overall at 24,48 and 72h
Score:
1
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: overall at 24,48 and 72h
Score:
0
Irritation parameter:
iris score
Basis:
animal #3
Time point:
other: overall at 24,48 and 72h
Score:
0
Other effects:
In addition to the effects scored, 2 animals showed slight conjunctival discharge during the first 24 hours post-administration. There were no eye effects noticeable by day 8.

Applicant's summary and conclusion

Interpretation of results:
other: not classified