Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: comparable to guidelines/standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Principles of method if other than guideline:
Estimation by quotient of the solubility in n-octanol and in water.
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: C-Wax Type E
Purity: 99.5-100% (w/w)

Study design

Analytical method:
other: weighing of dry residue

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.2
Temp.:
20 °C
Remarks on result:
other: pH not given
Details on results:
Due to the poor solubility of the test substance in water as well as in n-octanol the shake-flask method could not be applied. There is no analytical method available to determine low concentrations of the test substance. The HPLC method according to OECD guideline 117 is also not applicable since the test substance is not soluble in appropriate solvents.
Therefore the partition coefficient was estimated as quotient of the solubility in n-octanol and in water.

Any other information on results incl. tables

Result:

n-Octanol solubility:

Flask No.

Equilibration time at
20 °C
[h]

Content of test
substance

[mg/L]

1

2

72
72

483
541

mean

--

512

Water solubility:

Flask No.

Equilibration time at
20 °C

[h]

Content of test
substance
[mg/L]

1

2

72
72

13
1

mean

---

7

Log Pow range:

Log (483/13) = 1.6

Log (541/13) = 1.6

Log (483/1) = 2.7

Log (541/1) = 2.7

Mean Log Pow= 2.2

Applicant's summary and conclusion

Conclusions:
The test substance has a log Pow of 2.2.
Executive summary:

The partition coefficient of the test substance was estimated as quotient of the solubility in n-octanol and in water, as its solubility is too low for other log Pow determinations. The test substance has a log Pow of 2.2.