Registration Dossier
Registration Dossier
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EC number: 411-410-8 | CAS number: 118562-73-5
Endpoint summary
Administrative data
Description of key information
The test article "Hydroxyambran" can be classified as "not skin irritant".
The test article "Hydroxyambran" is to classify as "irritant to eyes" with reversible action.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The acute dermal iritation/corrosion of Hydroxyambran was determined according to the OECD Test Guideline 404 in rabbits.
Not any sign for irritation/corrosion was observed.
The test article "Hydroxyambran" can be classified as "not skin irritant".
The acute eye iritation/corrosion of Hydroxyambran was determined according to the OECD Test Guideline 405 in rabbits.
In 2 of 3 animals a mean score of 2.0 for conjunctivae, redness with full reversibitity within 6 days was observed.
According to the classification system in the REGULATION (EU) 1272/2008 is the test article "Hydroxyambran" to classify as "irritant" with reversible action.
Justification for selection of skin irritation / corrosion endpoint:
Not any sign for irritation/corrosion was observed.
Justification for selection of eye irritation endpoint:
In 2 of 3 animals a mean score of 2.0 for conjunctivae, redness with full reversibitity within 6 days was observed.
According to the classification system in the REGULATION (EU) 1272/2008 is the test article "Hydroxyambran" to classify as "irritant" with reversible action.
Effects on eye irritation: irritating
Justification for classification or non-classification
The acute dermal iritation/corrosion of Hydroxyambran was determined according to the OECD Test Guideline 404 in rabbits.
Not any sign for irritation/corrosion was observed.
The test article "Hydroxyambran" can be classified as "not irritant".
The acute eye iritation/corrosion of Hydroxyambran was determined according to the OECD Test Guideline 405 in rabbits.
In 2 of 3 animals a mean score of 2.0 for conjunctivae, redness with full reversibitity within 6 days was observed.
According to the classification system in the REGULATION (EU) 1272/2008 is the test article "Hydroxyambran" to classify as "irritant" with reversible action.
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