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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1986
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Principles of method if other than guideline:
see attached report
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(2,6-dimethylphenoxy)acetone
EC Number:
258-292-2
EC Name:
1-(2,6-dimethylphenoxy)acetone
Cas Number:
53012-41-2
Molecular formula:
C11H14O2
IUPAC Name:
1-(2,6-dimethylphenoxy)propan-2-one
Test material form:
other: liquid undiluted
Details on test material:
- Name of test material (as cited in study report): 2,6-Dimethylphenoxyaceton

Test animals

Species:
rat
Strain:
other: Chbb:THOM
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Fa. Dr. K. Thomae, Biberach/Riß
- Age at study initiation: 56 - 57 days
- Weight at study initiation: male ca. 235.0 g ; female ca. 168.8 g
- Fasting period before study: 16 - 20 hours before application
- Housing: : Animals were housed individually in Makrolon cages type III
- Diet (e.g. ad libitum): ad libitum Altromin R 8013
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 26
- Humidity (%): 50 - 65
- Photoperiod (hrs dark / hrs light ) : 12 : 12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1.6, 2.5 and 4.0 mL/kg corresponds to:
1648, 2575 and 4120 mg/kg
No. of animals per sex per dose:
5 animals per sex per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations : clinical signs - permanent during Day 1 , than once or twice a day until Day 14
body weight - Day before application , Day 8 + 15
- Necropsy of survivors performed: yes
Statistics:
Males:Probitanalyse
Females: logarithmic transformation of Dose-Values according Kärber-Procedure

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 880 - 3 090 mg/kg bw
Based on:
test mat.
Mortality:
Male, 2575 mg/kg , Number of animals : 5 ; Number of deaths : 3
Male, 4120 mg/kg , Number of animals : 5 ; Number of deaths : 3

Female, 2575 mg/kg , Number of animals : 5 ; Number of deaths : 2
Female, 4120 mg/kg , Number of animals : 5 ; Number of deaths : 5

12 animals died within 24 hours after application, 1 animal died on Day 2 after application
Clinical signs:
other: face-down and lateral position, reduced motility, gasping, tachypnoe, vocalization, lacrimation, ataxia, salvia, coma, ( see full study report )
Gross pathology:
see full study report

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
In conclusion, according to the Globally Harmonized Classification System, 2,6-Dimethylphenoxyaceton administered orally in male and female rats under the conditions of this study is considered that 2,6-Dimethylphenoxyaceton has not to be classified with an LD 50 of 2880 mg/kg bw.