Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Testing for sensitizing properties of 3 -chloro-o-toluidine was performed in female Pirbright white guinea pigs according to the method of Buehler as described in the OECD 406. Dermal induction was performed using 100% test substance. The control group was exposed to semi-liquid paraffin only. First challenge treatment was carried out with 100% test substance, second challenge treatment was performed with 50% test substance in petrolatum. After first challenge treatment two of 20 animals of the treatment group showed well defined erythema 24 hours after removal of the patches. Second challenge treatment resulted in very slight to well-defined erythema, dry rough skin and fine scales in three of 20 animals of the treatment group 24 and 48 hours after removal of the patches. The animals of the control group showed no signs of irritation after the first and second challenge treatment. Based on the results of this study 3-chloro-o-toluidine showed evidence for sensitizing properties.
Migrated from Short description of key information:
Sensitising (GLP Guideline Study, Hoechst, 94.0006, 1994)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
no data available
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available study is considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is considered to be classified for skin sensitsation (R43) under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is considered to be classified for skin sensitisation (Category 1B) under Regulation (EC) No. 1272/2008.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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