Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Specific investigations: other studies
Administrative data
- Endpoint:
- methaemoglobinaemia
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- Gesellschaft Deutscher Chemiker
- Year:
- 1 990
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
- Reference Type:
- publication
- Title:
- Biomonitoring of aromatic amines. II. Hemoglobin binding of some monocyclic aromatic amines.
- Author:
- Bierner and Neumann
- Year:
- 1 988
- Bibliographic source:
- Arch. Toxicol. 62, pp. 110-115
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Measurement of methaemglobin after oral application of test substance in rats.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- acute toxicity: oral
Test material
- Reference substance name:
- 5-chloro-o-toluidine
- EC Number:
- 202-452-6
- EC Name:
- 5-chloro-o-toluidine
- Cas Number:
- 95-79-4
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 5-chloro-2-methylaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- single treatment
- Frequency of treatment:
- once
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
85 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Examinations
- Examinations:
- measurement of methaemglobin 1.5 hours after application
Results and discussion
- Details on results:
- Maximal methaemglobin level of 2.0 ± 0.4% was observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
