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Diss Factsheets
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EC number: 403-360-0 | CAS number: 42405-40-3 BONTRON E-84; E-84
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc is a mono constituent substance. No studies on the toxicokinetics of the substance are available. Only limited data has been provided by ECHA via an inquiry result. No human data is available and the toxicokinetic analysis is based on physicochemical data and other relevant data. Based on this data, oral absorption can be expected, there is potential for distribution and metabolism and excretion may be affected by hepatic toxicity.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Absorption
The substance has a molecular weight of 564.05 g/mol, a solubility in water of 187.7 mg/L pH 7 at 20.0°C and a log octanol/water partition coefficient value of log10 Pow of 2.32 at 18.0°C; with these properties the substance is likely to absorbed orally from the gastro-intestinal tract. The systemic toxicity noted in the acute oral toxicity and subacute oral toxicity studies confirms this assumption. For risk chemical safety assessment purposes, a default oral absorption of 50% is accepted.
As a powder, the D50 of 17.44 µm and log10 Pow of 2.32 indicates the potential for respiratory inhalation and absorption. No inhalational toxicity data is available for the powder form of the substance. For risk chemical safety assessment purposes, the default inhalation absorption rate of 100% is accepted.
Based on the physicochemical properties of the substance (molecular weight, log10 Pow value, chemical structure), dermal absorption of the substance is expected to be low. However, the ECHA guidance criteria (Chapter R.7C) state that 10 % dermal absorption is used when the molecular weight of the substance is > 500 and the log Pow is <-1 or >4, otherwise 100 % dermal absorption is used. In general, dermal absorption will not be higher than oral absorption, so a dermal absorption rate of 50% will be used for chemical safety assessment.
Metabolism, Distribution and Excretion
Due to its water solubility and lipophilicity the substance may partition into tissues. Indications of hepatic toxicity in the oral repeated dose studies suggest that the metabolism of the substance may be compromised. There is no direct evidence to indicate the route of excretion of the substance. The substance is expected to be excreted in the faeces due to its molecular weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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