Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Endpoint summary
Administrative data
Description of key information
Additional information
Several studies on plants are available for trifluoroacetic acid. Two keys studies were performed according to OECD 208 guideline on three different species. The lowest EC50 was measured for shoot growth of mung bean at 4.7 mg/kg DW and the NOEC was determined at 0.83 mg/kg DW for the three species. Nine other studies on hydroponic and atmospheric exposures of several plants species and on bioaccumulation of TFA supported these results. According to column 2 of REACH Annex IX and X, no further studies need to be conducted on terrestrial organisms for trifluoroacetic acid because direct and indirect exposure of soil is unlikely based on its low potential for adsorption to soil (log Kow = 0.79 and Kd= 0.94 L/kg at 25°C) and the soild compartment is included in the Chemical Safety Assessment.
No relevant data are available on birds or mammals however, it is assumed that there is no need to conduct a secondary poisoning assessment for trifluoroacetic acid based on low exposure and low toxicity considerations. Indeed, according to the triggering criteria described in R.16.5.3.5, the substance has a low potential for bioaccumulation (Log Kow < 3, not highly adsorptive, Log Koc= 0.94 l/kg) and low levels of incorporation have been measured in several aquatic and terrestrial organisms showing BCF values < 100. Moreover, acute toxicity results on mammals (rats) exposed via the oral route from day 10 to day 20 of gestation show only slight but transient changes without being predictive of any developmental effect.
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