Dibenzyl ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable and well documentd

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

2 animals of each sex used, one tested dose

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Dibenzyl ether

EC Number:

203-118-2

EC Name:

Dibenzyl ether

Cas Number:

103-50-4

Molecular formula:

C14H14O

IUPAC Name:

[(benzyloxy)methyl]benzene

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 h

Doses:

5.15 mL/Kg

No. of animals per sex per dose:

2

Control animals:

not required

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5.15 mL/kg bw

Based on:

test mat.

Remarks on result:

other: The density of dibenzylether is 1.0428 g/cm³ at 20°C. Therefore 5.15 ml/kg bw corresponds with 5.37 g/kg bw.

Any other information on results incl. tables

In this study report, the authors calculated a LD 50 for rabbits higher than 5.15 mL/Kg in an acute test after an exposure of 24 hours under occlusive conditions to dibenzyl oxide.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

In this study report, the authors calculated a LD 50 for rabbits higher than 5.15 mL/Kg in an acute test after an exposure of 24 hours under occlusive conditions to dibenzyl oxide.