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EC number: 603-094-7
CAS number: 125904-11-2
In an acute oral toxicity study, groups of 5 male and 5 female
Sprague-Dawley rats received single oral doses of the undiluted test
substance at 5000, 6250 or 7500 mg/kg bw after a fasting period of 24
hours. Food was re-offered 1 hour after dosing. Deaths occurred on days
1 and 2. A single male rat died in the group treated at 5000 mg/kg bw. A
total of 5 animals (3 males and 2 females) died in the group treated at
6250 mg/kg bw. A total of 8 animals (5 males and 3 females) died in the
group treated at 7500 mg/kg bw. Signs of toxicity were noted in all
treated animals; survivors appeared normal by day 4 (5000 and 6250 mg/kg
bw) or day 5 (7500 mg/kg bw). Individual and mean body weights increased
at each interval afetr dosing, with the exception of a single female
treated at 6250 mg/kg bw on day 13. No significant macroscopic findings
were noted at termination for surviving animals, while stomach distended
with food, forestomach with shaggy white or chalky white material
present, hindstomach reddened or pale with or without focal haemorrhage,
intestines reddened were observed in decent animals from all groups.
The LD50 was calculated to be 6327 mg/kg bw for both sexes combined.
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