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EC number: 695-022-6 | CAS number: 473278-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Jun 2011 – 17 Feb 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 308 (Aerobic and Anaerobic Transformation in Aquatic Sediment Systems)
- Version / remarks:
- 2002
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.4300 (Aerobic Aquatic Metabolism)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.4400 (Anaerobic Aquatic Metabolism)
- Version / remarks:
- 2008
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment: freshwater
- Details on source and properties of sediment:
- - Details on collection (e.g. location, sampling depth, contamination history, procedure):
Water/Sediment system 1: Anglersee; Leverkusen/North Rhine-Westphalia/Germany; small, reclaimed gravel pit which is used for fishing only.
Water/Sediment system 2: Wiehltalsperre; close to Wiehl near Gummersbach/North Rhine-Westphalia/Germany; fresh water dam that is used for the preparation of drinking water, water and sediment collected from the forebay Nespen.
Water and sediment were taken in 1 to 2 m distance to the lakefronts and filled separately in plastic containers. Sediment was obtained from the upper sediment layer (5 – 10 cm thickness). No pesticides were used for previous 5 years at both locations.
- Storage conditions: At ambient conditions in the laboratory
- Storage length prior to use: Overnight until start of equilibration
- Textural classification (i.e. %sand/silt/clay): sand (Water/Sediment system Anglersee), silt loam (Water/Sediment system Wiehltalsperre)
- pH at time of collection: 7.1 (Anglersee), 6.5 (Wiehltalsperre)
- Organic carbon (mg/kg): 5400 (Anglersee), 70000 (Wiehltalsperre)
- Redox potential (mv) initial/final:171 (Anglersee), 126 (Wiehltalsperre)
- CEC (meq/100 g): 3.4 (Anglersee), 8.6 (Wiehltalsperre)
- Sediment samples sieved: Sieved to 2 mm mesh-size - Duration of test (contact time):
- 101 d
- Initial conc.:
- 90 µg/L
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
- Volume of test solution/treatment: 400 μL of application solution were applied dropwise onto the water surface of the respective equilibrated test systems using a pipette.
- Test temperature: 20.0 °C
- pH: 6.7 (Anglersee), 4.7 (Wiehltalsperre)
- Continuous darkness: yes
- Other: The untreated test systems were equilibrated to study conditions for 12 days prior to application.
TEST SYSTEM
- Culturing apparatus: Special cylindrical glass containers (volume about 1000 mL, inner diameter about 10.5 cm, surface area about 86.6 cm2) were used as test vessels and each container was fitted with a glass stirrer for smoothly movement of the water layer.
- Number of culture flasks/concentration: 16
- Method used to create aerobic conditions: Stirrer and trap attachments were permeable for oxygen. As from DAT-0 to DAT-3 decreasing oxygen contents and redox potentials were observed in the water layer, the velocity of the shaker was increased from 60 rpm at DAT-0 to 65 rpm at DAT-3 and further to 70 rpm from DAT-7 onwards.
- Details of trap for CO2 and volatile organics if used: Every container had a trap attachment (permeable for oxygen) containing soda lime for absorption of carbon dioxide and a polyurethane (PU) foam plug for adsorption of volatile organic compounds.
- Other: For preparation of the test systems, wet sediment with a weight equivalent to a volume of 175 mL was filled into each test vessel and 520 mL of the corresponding water were added.
SAMPLING
- Sampling frequency: Duplicate samples were processed and analyzed 0, 3, 7, 14, 30, 50, 70 and 101 days after treatment (DAT).
- Sample storage before analysis:
The PU foam plugs were processed and analyzed within 1 day after sampling.
The soda lime traps were stored before processing at ambient temperature in the laboratory for a maximum period of 12 weeks.
For determination of dissolved carbon dioxide subsamples of water were made alkaline and stored before processing for a maximum period of 12 weeks.
Water and sediment extracts were stored in a freezer in the dark. The maximum sample storage period was 35 days.
The exhaustive extracted sediments were lyophilized and stored at ambient temperature in the laboratory. - Compartment:
- natural water / sediment: freshwater
- % Total extractable:
- 93.4
- % Non extractable:
- 5.7
- % CO2:
- 0.7
- % Other volatiles:
- < 0.1
- % Recovery:
- 99.8
- Remarks on result:
- other:
- Remarks:
- Radioactivity distribution in the water/Sediment system Anglersee after 101 days
- Compartment:
- natural water / sediment: freshwater
- % Total extractable:
- 46.7
- % Non extractable:
- 48.1
- % CO2:
- 1
- % Other volatiles:
- < 0.1
- % Recovery:
- 95.8
- Remarks on result:
- other:
- Remarks:
- Radioactivity distribution in the water/Sediment system Wiehltalsperre after 101 days
- Parent/product:
- parent
- Compartment:
- total system
- % Degr.:
- 0.7
- Parameter:
- radiochem. meas.
- Sampling time:
- 101 d
- Remarks on result:
- other:
- Remarks:
- Mineralisation to 14CO2 after 101 days in the water/sediment system Anglersee
- Parent/product:
- parent
- Compartment:
- total system
- % Degr.:
- 1
- Parameter:
- radiochem. meas.
- Sampling time:
- 101 d
- Remarks on result:
- other:
- Remarks:
- Mineralisation to 14CO2 after 101 days in the water/sediment system Wiehltalsperre
- Compartment:
- natural water: freshwater
- DT50:
- 24.2 d
- Type:
- other: Single first order (SFO)
- Temp.:
- 20 °C
- Remarks on result:
- other:
- Remarks:
- Water/Sediment system: Anglersee
- Compartment:
- natural water: freshwater
- DT50:
- 51.4 d
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 12 °C
- Remarks on result:
- other:
- Remarks:
- Calculated DT50 based on results at 20 °C in water/sediment system Anglersee
- Compartment:
- natural water / sediment: freshwater
- DT50:
- 35.1 d
- Type:
- other: Single first order (SFO)
- Temp.:
- 20 °C
- Remarks on result:
- other:
- Remarks:
- Water/Sediment system: Anglersee
- Compartment:
- natural water / sediment: freshwater
- DT50:
- 74.5 d
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 12 °C
- Remarks on result:
- other:
- Remarks:
- Calculated DT50 based on results at 20 °C in water/sediment system Anglersee
- Compartment:
- natural water: freshwater
- DT50:
- 6.3 d
- Type:
- other: Double first order in parallel (DFOP)
- Temp.:
- 20 °C
- Remarks on result:
- other:
- Remarks:
- Water/Sediment system: Wiehltalsperre
- Compartment:
- natural water: freshwater
- DT50:
- 13.4 d
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 12 °C
- Remarks on result:
- other:
- Remarks:
- Calculated DT50 based on results at 20 °C in water/sediment system Wiehltalsperre
- Compartment:
- natural water / sediment: freshwater
- DT50:
- 20.8 d
- Type:
- other: Double first order in parallel (DFOP)
- Temp.:
- 20 °C
- Remarks on result:
- other:
- Remarks:
- Water/Sediment system: Wiehltalsperre
- Compartment:
- natural water / sediment: freshwater
- DT50:
- 44.2 d
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 12 °C
- Remarks on result:
- other:
- Remarks:
- Calculated DT50 based on results at 20 °C in water/sediment system Wiehltalsperre
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- No.:
- #4
- Details on transformation products:
- - Maximum occurrence of each transformation product: Four degradation products were identified with the following maximum amounts: AE 1392936 with 33.1% AR at DAT-101 in water/sediment system Anglersee, tefuryltrione-acetic-benzoic acid with 26.5% AR at DAT-70 in water/sediment system Anglersee, AE 0327513 with 27.1% AR at DAT-101 in water/sediment system Anglersee and tefuryltrione-isophthalic acid with 22.4% AR at DAT-101 in water/sediment system Wiehltalsperre.
- Evaporation of parent compound:
- no
- Volatile metabolites:
- no
- Residues:
- yes
- Details on results:
- TEST CONDITIONS
- Aerobicity (or anaerobicity), moisture, temperature and other experimental conditions maintained throughout the study: Yes
MAJOR TRANSFORMATION PRODUCTS
- Range of maximum concentrations in % of the applied amount and day(s) of incubation when observed: Four degradation products were identified with the following maximum amounts: AE 1392936 with 33.1% AR at DAT-101 in water/sediment system Anglersee, tefuryltrione-acetic-benzoic acid with 26.5% AR at DAT-70 in water/sediment system Anglersee, AE 0327513 with 27.1% AR at DAT-101 in water/sediment system Anglersee and tefuryltrione-isophthalic acid with 22.4% AR at DAT-101 in water/sediment system Wiehltalsperre.
TOTAL UNIDENTIFIED RADIOACTIVITY (RANGE) OF APPLIED AMOUNT:
The total unidentified residues amounted to a maximum of 4.3% AR and no single component exceeded 4.0% AR at any sampling interval for both water/sediment systems.
EXTRACTABLE RESIDUES
- % of applied amount at day 0: Extractable residues in the sediment of water/sediment system Anglersee increased from 0.7% AR at DAT-0 to 28.2% AR at DAT-30 and declined then to 18.4% AR at DAT-101. Extractable residues in the sediment of water/sediment system Wiehltalsperre increased from 1.4% AR at DAT-0 to 23.0% AR at DAT-30 and declined then to 22.5% AR at DAT-101.
NON-EXTRACTABLE RESIDUES
- % of applied amount at day 0: Non-extractable residues (NER) in water/sediment system Anglersee increased from 0.5% AR at DAT-0 to 8.9% AR at DAT-30 and decreased to 5.7% AR at DAT-101. In water/sediment system Wiehltalsperre NER increased from 2.4% AR at DAT-0 to 54.5% AR at DAT-50 and decreased to 48.1% AR at DAT-101.
MINERALISATION
- % of applied radioactivity present as CO2 at end of study: The maximum amount of carbon dioxide at study end (DAT-101) was 0.7% AR in water/sediment system Anglersee and 1.0% AR in water/sediment system Wiehltalsperre.
VOLATILIZATION
- % of the applied radioactivity present as volatile organics at end of study: Formation of volatile organic compounds (VOC) was insignificant as demonstrated by values of < 0.1% AR at all sampling intervals for both water/sediment systems. - Validity criteria fulfilled:
- not applicable
Reference
Description of key information
DT50 in freshwater sediment at 20 °C: 6.3 - 24.2 days (13.4 - 51.4 days, recalculated to 12 °C) in the water phase; 20.8 - 35.1 days (44.2 - 74.5 days, recalculated to 12 °C) in the total system, aerobic conditions (OECD 308)
Key value for chemical safety assessment
- Half-life in freshwater:
- 51.4 d
- at the temperature of:
- 12 °C
- Half-life in freshwater sediment:
- 74.5 d
- at the temperature of:
- 12 °C
Additional information
In a laboratory study, the route and rate of degradation of radiolabeled tefuryltrione was studied in two different water/sediment systems (sand, silt loam) under aerobic conditions in the dark for 101 days at 20.0 °C. The GLP study followed the OECD Guideline No. 308. After 101 days 0.7 and 1.0% of the applied radioactivity were mineralized to 14CO2. The half-life was 24.2 (sand system) and 6.3 (silt loam system) days (51.4 and 13.4 days, recalculated to 12 °C) in the water phase and 35.1 (sand system) and 20.8 (silt loam system) days (74.5 and 44.2 days, recalculated to 12 °C) in the total system.
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