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Diss Factsheets
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EC number: 205-517-7 | CAS number: 141-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- O-isopropyl ethylthiocarbamate
- Type of composition:
- boundary composition of the substance
- State / form:
- liquid
- >= 85 - < 100 % (w/w)
- Reference substance:
- O-isopropyl ethylthiocarbamate
- Reference substance:
- O-isopropyl ethylthiocarbamate
- This impurity is considered relevant for the classification and labelling of the substance
- Reference substance:
- O-isopropyl ethylthiocarbamate
- This impurity is considered relevant for the classification and labelling of the substance
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Annex XIII of the REACH Regulation (1907/2006) lays down the criteria for the identification of persistent, bioaccumulative and toxic substances (PBT substances), as well as the information that must be considered for the purpose of assessing the P, B, and T properties of the substance. The criteria require that all available information is to be used, employing a weight-of-evidence approach. Substances must meet all three criteria to be considered PBT.
Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are both reagents used in the manufacture of IPETC/ O-isopropyl ethyl thiocarbamate. Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethyl thiocarbamate .
The results suggest that Propan-2-ol (Isopropyl alcohol) and Butan-1-ol (Butyl alcohol) are readily biodegradable and therefore IPETC/ O-isopropyl ethylthiocarbamate will be readily biodegradable and it is not expected to persist in the environment.
Therefore, IPETC/O-isopropyl ethylthiocarbamate is not persistent.
Bioaccumulation Assessment:
Bioaccumulation is considered to be low for IPETC/ O-isopropyl ethylthiocarbamate which is rapidly metabolised in higher organisms.
The estimated Log BCF of IPETC/O-isopropyl ethylthiocarbamate is 1.86 (BCF = 71.8 L/kg wet-wt).This substance has a limited potential to bioaccumulate (based on log Kow used by BCF estimates: 3.32, and predicted bioconcentration factors, log BCF = 1.86 (EPIWIN/BCF Program).
Two evidences result in the conclusion that IPETC/ O-isopropyl ethylthiocarbamate is not expected to be B/vB:
-The chemical belongs to the thiocarbamate group. In general, thiocarbamates are absorbed via the skin, mucous membranes, respiratory and gastrointestinal tracts, with rapid elimination via expired air and urine.
-Thiocarbamates are also rapidly metabolised, producing either mercapturic acid compounds or compounds that enter the carbon metabolic pool
Therefore, IPETC/ O-isopropyl ethylthiocarbamate is not considered to be bioaccumulative.
Toxicity Assessment:
None of the long-termEC10 or NOECs for marine or freshwater organisms are below 0.01 mg/L. IPETC/ O-isopropyl ethylthiocarbamate is not classified as carcinogenic (Category 1 or 2), mutagenic (Category 1 or 2), or toxic for reproduction (Category 1, 2 or 3). There is no evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC. Therefore IPETC/ O-isopropyl ethylthiocarbamate does not meet the PBT criteria for toxicity.
Summary and overall Conclusions on PBT or vPvB:
Properties Based on the data collected and the discussion above,IPETC/ O-isopropyl ethylthiocarbamate does not meet the criteria for either PBT or VPvB as it is readily biodegraded in the environment, has a very low bioaccumulation potential, low chronic aquatic toxicity and is not classified as carcinogenic, mutagenic, or toxic for reproduction or for chronic toxicity.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.