Registration Dossier
Registration Dossier
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EC number: 209-513-6 | CAS number: 583-60-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- No description of the guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylcyclohexanone
- EC Number:
- 209-513-6
- EC Name:
- 2-methylcyclohexanone
- Cas Number:
- 583-60-8
- Molecular formula:
- C7H12O
- IUPAC Name:
- 2-methylcyclohexan-1-one
- Test material form:
- liquid
- Details on test material:
- As received, undiluted, the sample was observed to be a free-flowing
clear liquid.
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 1 370 - <= 2 868 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated value considering LD50 value reported in mL/Kg, converted to mg/Kg by considering density
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 1.48 - <= 3.1 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: value as reported in the study
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The 2-methylcyclohexanone and the source cyclohexanone show similar single oral toxicity in rats, with a slight lesser toxic dose for the target compound 2-methylcyclohexanone (Smyth et al., 1969):
• 2-methylcyclohexanone LD50: 2.14 (1.48-3.10) ml/kg
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