Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 May - 14 Jun 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Remarks:
Food and Consumer Product Safety Authority, Den Haag, The Netherlands
Type of method:
other: estimation method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): PM-5927
- Physical state:off-white powder
- Lot/batch No.:07-02
- Expiration date of the lot/batch:05.02.2008
- Storage condition of test material: at room temperature protected from light

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
34
Temp.:
20 °C
Type:
log Pow
Partition coefficient:
1.53
Temp.:
20 °C

Any other information on results incl. tables

Results

No test substance was detected in the pretreated samples from the blank octanol mixture. No tendency to increased values was obtained. However, the spread on the analysed concentrations was relatively high i.e. a maximum difference (MD) of > 15%. To investigate the reason for it, it was decided to perform a second main study.

Study #

Stirring time [hours]

Individual

[g/L]

Analysed concentration

Mean 1 [g/L]

Mean 2 [g/L]

MD [%]

1

24

17.7

17.7

18.1

25.8

1

24

17.8

1

48

15.8

15.9

1

48

15.9

1

72

20.4

20.6

1

72

20.8

2

24

16.7

16.9

18.0

27.9

2

24

17.1

2

48

16.0

16.0

2

48

16.0

2

72

21.1

21.2

2

72

21.2

In the second main study, similar results as during main study 1 were obtained. No possible reason for the relatively high spreads on the analysed concentrations could be given. The results were therefore accepted and the n-octanol solubility was calculated using the results of main study 1 and 2. The mean n-octanol solubility is 18.0 g/L.

Water solubility

The water solubility was 0.530 g/L.

The Pow, calculated as the quotient of the octanol- and water solubility, is 34.0. It corresponds with a log Pow value of 1.53.

Applicant's summary and conclusion