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EC number: 949-211-8
CAS number: -
Rabbit (m/f) (OECD 404): not irritating (BASF AG, 1984)
Actually there is no date available
Rabbit (m/f) (OECD 405): not irritating (BASF AG, 1984)
following considerations based on the similar substance are also
applicable to the target substance. For read across justification see
the relevant document in the read across section
valid in vivo data available for the assessment of the skin and eye
irritation potential of the test substance.
potential of the test substance to cause acute dermal irritation or
corrosion was assessed in vivo in
rabbits according to OECD guideline 404. In this study the test article
did not show any irritative/corrosive potential by a single topical
application of 0.5 g of the test substance to the intact skin of 3 White
Vienna rabbits for 4 hours under semiocclusive conditions. The average
score (24 to 72 hours) for irritation was calculated to be 0.1 for
erythema and 0.0 for edema, with the erythema being fully reversible
within 48 hours.
potential of the test substance to cause eye irritation or corrosion was
assessed in 3 rabbits according to OECD guideline 405. The test
substance produced moderate conjunctival reactions (reddening and
swelling) were observable in all animals for 24 h after exposure,
however, the eye was exposed to bulk volume (powder) of the test
substance, thus, initial irritation can be explained by mechanical
effects. Those effects were fully reversible within 8d. No other effects
following considerations based on EC 400 -720 -9 are also applicable to
EC: 700- 899 -6. For read across justification see the relevant document
in the read across section
the results of the in vivo experiments, the test substance needs not to
be labelled according to the criteria defined by the EU and the GHS
no indication given for a classification according to this endpoint
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