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EC number: 949-211-8
CAS number: -
Acute Oral toxicity
Rat: LD50 (m/f) > 2200 mg/kg bw (EU B.1; BASF AG, 1993)
Rat:LD50 (m/f) > 5000 mg/kg bw (OECD 401; BASF AG, 1984)
following considerations based on EC 400 -720 -9 are also applicable to
EC: 700- 899 -6. For read across justification see the relevant document
in the read across section
are valid, guideline conform, in vivo data available for the assessment
of the acute toxicity of the test substance.
oral toxicity of the test substance was investigated in two groups of 3
male and 3 female rats according to EU B.1/OECD 401 guideline, given a
limit dose of 2200 mg/kg bw as gavage. Clinical signs were discoloured
feces for male and female rats and piloerection and smeared fur in the
anogenital area in male animals. No mortality or gross pathological
changes were reported.
second study the acute oral toxicity of the test substance was
investigated according to OECD guideline 401 in two groups of 3 male and
3 female rats, given a limit dose of 5000 mg/kg bw as gavage. Clinical
signs were black feces for male and female rats. No mortality or gross
pathological changes were reported.
dust inhalation toxicity of the test substance was investigated
according to OECD 403 guideline in 5
male and 5 female rats. The test material was applied as dust (dust
generator; dose determination: gravimetrically) via head/nose inhalation
at a limit dose level of 5200 mg/m3 for 4 hours. Clinical signs during
exposure were attempts to escape and irregular breathing. After exposure
no deaths and no signs of toxicity were noted.
data to assess the acute dermal toxicity of the test article are not
on the criteria defined by the EU and the GHS system, the test substance
needs not to be labelled for acute oral toxicity because no death
occurred in the highest dosing group of 5000 mg/kg bw in male and female
animals that could be attributed to the test substance administration.
acute inhalation toxicity the test substance needs also not to be
labelled according to the criteria defined by the EU and the GHS system
since no death occurred at the highest dose level of 5200 mg/l.
there is no indication given for a classification according to this
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