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EC number: 233-108-3 | CAS number: 10034-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- skin irritation: tissue viability 29.5 %, skin irrirtant category 2 (prediction by OECD QSAR Toolbox v4.3.1, 2019; based on experimental results of closely related analogue Lithium perchlorate)
- eye irritation: IVIS value 47.1, eye irritant category 2 (prediction by OECD QSAR Toolbox v4.3.1, 2019; based on experimental results of closely related analogue Lithium perchlorate)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in silico, (Q)SAR performed with OECD QSAR Toolbox, Read Across analysis
- Type of information:
- other: (Q)SAR from supporting substance (structural analogue or surrogate) for which an in vivo result is available
- Adequacy of study:
- key study
- Study period:
- 2019-03-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification, with an experimental result (as provided by the OECD QSAR Toolbox)
- Justification for type of information:
- 1. SOFTWARE
OECD QSAR Toolbox v4.3.1
2. MODEL (incl. version number)
Read Across analysis
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to 'Attached justification'
5. APPLICABILITY DOMAIN
Please refer to 'Attached justification' - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: OECD QSAR Toolbox v4.3.1
- Model(s) used: Read Across analysis
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification' - GLP compliance:
- no
- Remarks:
- Not applicable (QSAR calculation)
- Specific details on test material used for the study:
- SMILES: [Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 29.5
- Remarks on result:
- positive indication of irritation
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The skin irritating potential of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The tissue viability was predicted to be 29.5 %.
Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of the closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is considered entirely appropriate for the assessment of the skin and eye corrosion/irritation potential of Magnesium perchlorate.
The predicted tissue viability of 29.5 % is below the cut off value for classification, which is = 50 % as stated in OECD TG 439, identifying a test chemical as requiring classification and labelling according to UN GHS (Category 2 or Category 1). The RhE test methods covered by OECD TG 439 cannot resolve between UN GHS Categories 1 and 2.
As indicated above this prediction is based on the experimental result for the analogue substance Lithium perchlorate. In comparison closely related perchlorates like Potassium, Sodium and Ammonium perchlorate are neither classified as skin irrit. 1 nor as skin irrit. 2 in accordance with Annex VI of Regulation (EC) No. 1272/2008 (CLP Regulation). Furthermore Magnesium is known to be non-toxic to human health, while Lithium is known to be corrosive and classified as corrosive to the skin according to Regulation (EC) No 1272/2008 CLP (Cat. 1B, H314) and according to Directive 67/548/EEC (R34). Therefore it was considered entirely appropriate to classify Magnesium perchlorate as skin irrit 2 as worst-case assumption. - Executive summary:
The skin irritating potential of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The tissue viability was predicted to be 29.5 %.
Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of the closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is considered entirely appropriate for the assessment of the skin and eye corrosion/irritation potential of Magnesium perchlorate.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- in silico, (Q)SAR performed with OECD QSAR Toolbox, Read Across analysis
- Type of information:
- other: (Q)SAR from supporting substance (structural analogue or surrogate) for which an experimental result is available
- Adequacy of study:
- key study
- Study period:
- 2019-03-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification, with an experimental result (as provided by the OECD QSAR Toolbox)
- Justification for type of information:
- 1. SOFTWARE
OECD QSAR Toolbox v4.3.1
2. MODEL (incl. version number)
Read Across analysis
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to 'Attached justification'
5. APPLICABILITY DOMAIN
Please refer to 'Attached justification' - Guideline:
- other: ECHA Guidance R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: OECD QSAR Toolbox v4.3.1
- Model(s) used: Read Across analysis
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification' - GLP compliance:
- no
- Remarks:
- Not applicable (QSAR calculation)
- Specific details on test material used for the study:
- [Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
- Irritation parameter:
- in vitro irritation score
- Value:
- 47.1
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The eye irritating potential of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The in vitro irritation score was predicted to be 47.1.
Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of the closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is considered entirely appropriate for the assessment of the skin and eye corrosion/irritation potential of Magnesium perchlorate.
The predicted IVIS value of 47.1 is above the cut-off value of 3 (UN GHS no category) and below the cut-off value of 55 (UN GHS Category 1) as stated in OECD TG 437. Consequently no prediction concerning irritant or severely irritant potential of the test item can be made.
As indicated above this prediction is based on the experimental result for the analogue substance Lithium perchlorate. In comparison closely related perchlorates like Potassium and Ammonium perchlorate are classified as eye irrit. 2, while Sodium perchlorate is not classified as eye irritant at all in accordance with Annex VI of Regulation (EC) No. 1272/2008 (CLP Regulation). In addition Magnesium is known to be non-toxic to human health, while Lithium is classified as corrosive to skin and eye: "causes severe skin burns and eye damage" (Cat. 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC. Therefore it was considered entirely appropriate to classify Magnesium perchlorate as eye irrit 2 as worst-case assumption. - Executive summary:
Eye irritation of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The in vitro irritation score was predicted to be 47.1.
Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of the closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is considered entirely appropriate for the assessment of the skin and eye corrosion/irritation potential of Magnesium perchlorate.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The skin irritation and eye irritation of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the closely analogue substance Lithium perchlorate (CAS 7791-03-9). This analogue was tested for its eye irritation and skin irritation according to OECD 437 and OECD TG 439, respectively. Since the perchlorate is considered to trigger the toxicity, this approach is justified and considered as entirely appropriate to draw conclusions on the skin and eye irritation of Magnesium perchlorate. However, the registrant is prepared to conduct an experimental study but considered it as not necessary at first instance taking into account the available results.
Justification for classification or non-classification
- skin irritation: The predicted tissue viability of 29.5 % is below the cut off value for classification, which is </= 50 % as stated in OECD TG 439, identifying a test chemical as requiring classification and labelling according to UN GHS (Category 2 or Category 1). As indicated above this prediction is based on the experimental result for the analogue substance Lithium perchlorate. In comparison closely related perchlorates like Potassium, Sodium and Ammonium perchlorate are neither classified as skin irrit. 1 nor as skin irrit. 2 in accordance with Annex VI of Regulation (EC) No. 1272/2008 (CLP Regulation). Furthermore Magnesium is known to be non-toxic to human health, while Lithium is known to be corrosive and classified as corrosive to the skin according to Regulation (EC) No 1272/2008 CLP (Cat. 1B, H314) and according to Directive 67/548/EEC (R34). Therefore it was considered entirely appropriate to classify Magnesium perchlorate as skin irrit 2 as worst-case assumption.
- eye irritation: The predicted IVIS value of 47.1 is above the cut-off value of 3 (UN GHS no category) and below the cut-off value of 55 (UN GHS Category 1) as stated in OECD TG 437. Consequently no prediction concerning irritant or severely irritant potential of the test item can be made. As indicated above this prediction is based on the experimental result for the analogue substance Lithium perchlorate. In comparison closely related perchlorates like Potassium and Ammonium perchlorate are classified as eye irrit. 2, while Sodium perchlorate is not classified as eye irritant at all in accordance with Annex VI of Regulation (EC) No. 1272/2008 (CLP Regulation). Additionally Magnesium is known to be non-toxic to human health, while Lithium is classified as corrosive to skin and eye: "causes severe skin burns and eye damage" (Cat. 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC. Therefore it was considered entirely appropriate to classify Magnesium perchlorate as eye irrit 2 as worst-case assumption.
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