Amines, N-tallow alkyltrimethylenedi-, reaction products with epichlorohydrin

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25.7.2018 - 02.08.2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

other: gas chromatography method

Principles of method if other than guideline:

The objective of this study was to determine the Vapor pressure of the test item, polyflow 130 using Gas chromatography method.
Following equipments were used in the study: Gas Chromatograph GC-2010 plus (Shimadzu, Japan)

The solvent n-Hexane was used as diluent and as well as reference item.
A Gas Chromatography involves equilibrium between volatile solute, solvent and an inert gas used as a carrier gas. A very basic equation relating the net solute retention time “t” at Temperature “T” in a solvent is given by
tx pos
--- = ------
ts pox

where tx = retention time of unknown solute in solvent
ts = retention time of reference solute in solvent
pos =Vapor pressure of reference solute in solvent
pox = Vapor pressure of unknown solute in solvent

The method was developed using GC – FID taking the following points in to consideration.
• The test item physical state was viscous liquid resembling peanut oil.
• The boiling point of the test item was 215.2 (sourced from study No., 8032)
• The vapor pressure of any test item equals 100 kPa (1atm pressure) at its boiling point
• The vapor pressure of the test item would be less than 100kPa, since water vapor pressure matches 100kPa at 100°C
• At 25°C the water vapor pressure is around 3.17 kPa, hence for the test item the vapor pressure would be less than 3.17kPa.
The reference items mentioned, having known pressures at 25°C was sourced from standard literatures mentioned and were prepared in n-hexane solvent and injected in to gas chromatography. The retention time of the individual reference item, which is based on their vapor pressure was recorded.

The calculations were carried out using Microsoft® Excel 2010. The values were interlinked and truncated to appropriate decimals based on its significance. There will be slight deviation in the final results if calculated using calculator.
Vapor pressure conversion factor = 133.322
Vapor pressure, mmHg x 133.322 = Vapor pressure, Pa
Regression equation = Y = bX + a
where Y = Ln (P°s)
b = Slope = -7.8506
X = Ln (ts)
a = Intercept = 14.6899

GLP compliance:

yes

Type of method:

other: Gas chromatogaphy

Specific details on test material used for the study:

Identification Polyflow 130
Appearance Yellow to amber colored liquid
Chemical Name Amines, N-tallow alkyltrimethylenedi-,reaction products with epichlorohydrin
Batch No. ST-637
CAS No. 93821-29-5
Molecular weight Not available
Molecular Formula Not available
Purity (%) Not available
Manufacturing date March, 2018
Expiry date Feb, 2020
Stability The product is stable under storage at normal ambient temperature
Storage conditions Room Temperature (20 to 30ºC)
Safety precautions Aprons, masks, caps, gloves and goggles were used to ensure the health and safety of the personnel

Key result

Temp.:

25 °C

Vapour pressure:

1.3 Pa

The test item Vapor pressure was determined by gas chromatography method. The reference items were chosen such a way that the retention time covers the test item retention time. A natural logarithms data plot was constructed using ln (t_s), the retention time and ln (P°_s), the known vapor pressure (at 25°C) of the reference items. The regression coefficient >0.90 reveals method suitability. The regression equation was used to derive the vapor pressure of polyflow 130. The details on data generated were given inTable -1

TABLE -1 VAPOR PRESSURE OF REFERENCE ITEMS AND TEST

  ITEM

Reference items	Retention time, Minutes (ts)			Ln (ts)	*Vapor pressure (P°s)			LN (P°s)
	R1	R2	Mean (ts)		mm Hg		Pa
Hexane	1.809	1.808	1.809	0.592	153.0	2.040E+04		9.92
Toluene	1.969	1.968	1.969	0.677	28.40	3.786E+03		8.24
Dimethyl phthalate	10.912	10.928	10.920	2.391	0.00308	4.106E-01		-0.89
Dibutyl phthalate	16.867	16.872	16.870	2.826	0.0000201	2.680E-03		-5.92
Chlorpyrifos	17.222	17.22	17.221	2.846	0.0000202	2.693E-03		-5.92
Tebuconazole	20.92	20.932	20.926	3.041	0.000000023	3.106E-06		-12.68
Permethrin	23.625	23.624	23.625	3.162	0.0000000518	6.906E-06		-11.88
Slope								-7.8506
Intercept								14.6899
Correlation coefficient								-0.9663
Regression coefficient								0.9338

*Data representing at 25°C were sourced from standard literatures

 

Vapor pressure of test item Replicate-1
Test item	RT (Min), tx			Ln(tx)	Vapor Pressure, Px
Polyflow 130	6.281			1.8375
Intercept(a)	Slope (b)	Ln (tx)	(b) x Ln (tx)	Ln (Px)	(Pa)
14.6899	-7.8506	1.8375	-14.4257	0.26	1.30
Vapor pressure of test item Replicate-1
Test item	RT (Min), tx			Ln(tx)	Vapor Pressure, Px
Polyflow 130	6.276			1.8367
Intercept(a)	Slope (b)	Ln (tx)	(b) x Ln (tx)	Ln (Px)	(Pa)
14.6899	-7.8506	1.8367	-14.4257	0.26	1.30

Conclusions:

The vapor pressure of the liquid test item was 1.30Pa, derived from known vapor pressure of reference items at 25°C.

Executive summary:

The test item Vapor pressure was determined by gas chromatography method. A Gas Chromatography involves equilibrium between volatile solute, solvent and an inert gas used as a carrier gas. The reference items were chosen such a way that the retention time covers the test item retention time. A natural logarithms data plot was constructed using ln (t_s), the retention time and ln (P°_s), the known vapor pressure (at 25°C) of the reference items. The regression coefficient >0.90 reveals method suitability. The regression equation was used to derive the vapor pressure of polyflow 130. The vapor pressure of the liquid test item was 1.30Pa

Description of key information

The vapour pressure (Polyflo130; GC): 1.30Pa at 25 °C

Key value for chemical safety assessment

Vapour pressure:

1.3 Pa

at the temperature of:

25 °C

Additional information

The test item Vapor pressure was determined by gas chromatography method.A Gas Chromatography involves equilibrium between volatile solute, solvent and an inert gas used as a carrier gas.The reference items were chosen such a way that the retention time covers the test item retention time. A natural logarithms data plot was constructed using ln (t_s), the retention time and ln (P°_s), the known vapor pressure (at 25°C) of the reference items. The regression coefficient >0.90 reveals method suitability. The regression equation was used to derive the vapor pressure of polyflow 130.