Registration Dossier
Registration Dossier
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EC number: 947-962-6 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Link to relevant study records
- Endpoint:
- two-generation reproductive toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see read across justification section 13.2
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 10 100 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- other: no effects reported at the highest dose tested.
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- > 10 100 mg/kg bw/day (actual dose received)
- Sex:
- male/female
- Basis for effect level:
- other: No effects on fertility of F1 generation wre observed at the highest dose.
- Dose descriptor:
- NOAEL
- Remarks:
- developmental effects, propylene glycol
- Generation:
- F2
- Effect level:
- ca. 10 100 mg/kg bw/day (actual dose received)
- Sex:
- male/female
- Basis for effect level:
- other: No effects on litter size, sex and pup weight in F2 pups were observed at the highest dose.
- Reproductive effects observed:
- not specified
- Executive summary:
The test substance has a NOAEL of 10 100 mg/kg bw/day in a two generation reprotox study.
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 126 mg/kg bw/day
- Study duration:
- chronic
- Species:
- mouse
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
