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Diss Factsheets
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EC number: 402-370-2 | CAS number: 149057-70-5 AOC 1020X
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November - december 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- EPA-821-R-02-013
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- 1981
- Principles of method if other than guideline:
- Similar conditions compared to OECD 201 assay regarding initial biomass and concentration, temperature range, test duration
- GLP compliance:
- yes
- Remarks:
- NELAC certification - generation of environmental laboratory data of known and documented quality in a cost-effective manner through the development of USA recognized standards for environmental laboratory accreditation
Test material
- Reference substance name:
- (ethyl-3-oxobutanoato-O'1,O'3)(2-dimethylaminoethanolato)(1-methoxypropan-2-olato)aluminium(III), dimerised
- EC Number:
- 402-370-2
- EC Name:
- (ethyl-3-oxobutanoato-O'1,O'3)(2-dimethylaminoethanolato)(1-methoxypropan-2-olato)aluminium(III), dimerised
- Cas Number:
- 149057-70-5
- Molecular formula:
- C14H28AlNO6
- IUPAC Name:
- octaaluminium(3+) octakis((2Z)-4-ethoxy-4-oxobut-2-en-2-olate) octakis(1-methoxypropan-2-olate) octakis(2-(dimethylamino)ethan-1-olate)
Constituent 1
- Specific details on test material used for the study:
- batch 0002294851
Sampling and analysis
- Analytical monitoring:
- no
- Remarks:
- complexe substance difficult to analyse
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- The freshwater algae Pseudokirchneriella subcapitata was obtained from the University of Waterloo, Canadian Phycological Culture Centre (Waterloo, Ontario, Canada). The algae were cultured in accordance with US EPA (2002b) methodology. Algae lot # PS-039 was received on 19 October 2018.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- moderately hard reconstituted water
- Test temperature:
- target temperature of 251C
- pH:
- measured at test initiation
- Dissolved oxygen:
- measured at test initiation
- Salinity:
- not specified
- Conductivity:
- measured at test initiation
- Nominal and measured concentrations:
- nominal 0.1, 1.0, 10, 100 and 1,000 mg/L.
- Details on test conditions:
- The Water-Accomodated Fractions (WAFs) of the sample were prepared following the guidance in the ASTM D6081-98 (ASTM 2004) Standard Practice. Chambers for the WAF preparation were 2-L glass beakers. The volume of moderately hard reconstituted water used to prepare the five different loads of WAF was 1500 ml, which represented a 1:1 height to diameter ratio in the 2-L beaker. The five loads of WAF were: 0.1 mg/L, 1.0 mg/L, 10 mg/L, 100 mg/L, and 1,000 mg/L. Once the correct weight of sample was loaded into the beakers, 1500 ml of media was slowly siphoned into each of the beakers. A stir bar was added to each beaker, and the beakers were then placed on stir plates for overnight mixing. The speed of the stirring was adjusted so that there was a vortex of approximately 15 percent of the water column. The loads were mixed for 21 hours at 25ºC after which the solutions were allowed to settle for three hours. The WAF preparations were siphoned out of the beakers for testing.
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- other: EC25
- Effect conc.:
- ca. 14.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 51.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- cell number
- Details on results:
- the mean cell density after 72 hours in the test concentrations ranged from 21,250 to 610,625 cells/ml
- Results with reference substance (positive control):
- mean cell density after 72 hours in the test concentration was 762,500 cells/ml in the control
The results of the reference toxicant tests were acceptable and fell within the established laboratory control chart limits. For P. subcapitata, the 96-hour EC50 was 0.45 mg/L Cr+6, and acceptable control chart range was 0-1.2 mg/L Cr+6. - Reported statistics and error estimates:
- Shapiro-Wilk's test indicates normal distribution (p>0.01)
Bartlett's test indicates equal variances (p=0.19)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the 72-hour Pseudokirchneriella subcapitata definitive acute toxicity test with the AOC 1020X, the mean cell density after 72 hours in the test concentrations ranged from 21,250 to 610,625 cells/ml, compared to 762,500 cells/ml in the control. The P. subcapitata 72-hour EC25 and EC50 were 14.8 and 51.7 mg/L AOC 1020X.
- Executive summary:
In the 72-hour Pseudokirchneriella subcapitata definitive acute toxicity test following US EPA standard EPA-821-R-02-013, the mean cell density after 72 hours in the test concentrations ranged from 21,250 to 610,625 cells/ml, compared to 762,500 cells/ml in the control. The P. subcapitata 72-hour EC25 and EC50 were 14.8 and 51.7 mg/L AOC 1020X.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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