Registration Dossier
Registration Dossier
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EC number: 213-322-3 | CAS number: 937-14-4
Endpoint summary
Administrative data
Description of key information
Fish: A single 96 -hour acute toxicity study in carp with 3 -chloroperoxybenzoic acid was based on OECD guideline 203 (1992). A final test was performed based on the results of two preceding range-finding tests. A Water Accommodated Fraction (WAF) was prepared at a loading rate of 1.0 mg/L and used as the highest concentration. Lower concentrations were prepared by diluting the highest concentration in test medium. Initial measured concentrations used were 0.11, 0.20, 0.34, 0.60 and 1.1 mg/L at 10, 18, 32, 56 and 100% of the WAF at 1.0 mg/L, respectively and remained stable. All fish exposed to 0.60 mg/L and higher died within 24 hours of exposure. No mortality or clinical effects were observed at any of the lower concentrations and the control during the 96 hour test period. The 96 -hour LC50 was 0.45 mg/L based on initially measured and stable concentrations (95% CI 0.34 -0.60 mg/L) and was already reached after 24 hours of exposure.
Invertebrates: ECOSAR v1.11 predicted 48-hr LC50 for Daphnids = 19.776 mg/L for (Peroxy Acids).
Algae: Following OECD guideline 201, 2006 (Annex 5 corrected 28 July 2011), the test substance 3 -chloroperoxybenzoic acid was tested for toxic effects in Psudokirchneriella subcapitata over 72 hours and the inhibition of growth rate and inhibition of yield were determined. Six replicates of exponentially growing algal cultures were exposed to a control, whereas three replicates per group were exposed to solutions containing 1.0, 3.2, 10, 32 and 100% of the WAF prepared at a loading rate of 10 mg/L. The initial algal cell density was 104 cells/mL and the total exposure period was 72 hours. Samples for analytical confirmation of exposure concentrations were taken at the start, after 24 and 72 hours of exposure. The measured initial concentrations were 0.093, 0.28, 0.85, 2.7, and 8.5 mg/L at 1.0, 3.2, 10, 32 and 100% of the WAF prepared at 10 mg/L. A dose-related inhibition of algal growth was found and 100% inhibition of both growth rate and yield was observed at 2.7 mg/L and higher. The EC50 based on growth rate was 1.0 mg/L (95% CL 0.97-1.1) and the EC50 based on yield was 0.49 mg/L (95% CL 0.47-0.52). The NOEC for growth rate based on statistical significance was 0.093 mg/L and based on biological relevance was 0.28. The NOEC for yield based on statistical significance or biological relevance was 0.093 mg/L.
Additional information
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