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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01.05.1995 - 24.07.1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
Sample solutions were prepared in each buffer solution at a nominal concentration of 2.0 g/L. The solutions were maintained at 50.0 +/- 0.5 °C in stoppered glass flasks for a period of 5 days.
The concentration of benzenebutanoic acid, 4-methyl-γ-oxo and 4-ethylmorpholine was monitored as follows:
Benzenebutanoic acid, 4-methyl-γ-oxo:
Samples:
Duplicate aliquots (A and B) of sample solutions were diluted by a factor of 20 with acetonitrile:water (50:50).
Standards:
Duplicate standard solutions were prepared in acetonitrile:water (50:50) at a nominal concentration of 50 mg/l or 100 mg/l.
4-Ethylmorpholine:
Samples:
Duplicate aliquots (A and B) of sample solutions were diluted by a factor of 2 with acetone.
Standards:
Duplicate standard solutions were prepared in acetone:buffer solution (1:1) at a nominal concentration of 1000 mg/l.
Buffers:
Potassium hydrogen phthalate 0.05 M (pH4 buffer)
Disodium hydrogen orthophosphate 0.04 M, Potassium dihydrogen orthophosphate 0.03 M (pH 7 buffer)
Disodium tetraborate 0.05 M, pH adjusted with hydrochloric acid (pH 9 buffer)
The above solutions were filtered through a 0.22 μm membrane.
Estimation method (if used):
The half-life at 25 °C was estimated from hydrolysis after 5 days at 50 °C in pH 4, 7 and 9 buffer solutions.
Duration:
45 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.836 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
120 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.836 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
2.4 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
1.46 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
24 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
1.51 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
120 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
1.49 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
2.4 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
1.53 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
24 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
1.53 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
120 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
1.54 g/L
Remarks:
Benzenebutanoic acid, 4-methyl-γ-oxo
Duration:
2.4 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.479 g/L
Remarks:
4-Ethylmorpholine
Duration:
120 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.501 g/L
Remarks:
4-Ethylmorpholine
Duration:
2.4 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
0.482 g/L
Remarks:
4-Ethylmorpholine
Duration:
120 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
0.494 g/L
Remarks:
4-Ethylmorpholine
Duration:
2.4 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
0.478 g/L
Remarks:
4-Ethylmorpholine
Duration:
120 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
0.476 g/L
Remarks:
4-Ethylmorpholine
Number of replicates:
2
Positive controls:
no
Negative controls:
no
Transformation products:
not measured
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Details on results:
Benzenebutanoic acid, 4-methyl-γ-oxo:
Less than 10 % hydrolysis after 5 days at 50 °C which equates to a half-life of greater than 1 year at 25 °C.

4-Ethylmorpholine:
Less than 10% hydrolysis after 5 days at 50 °C which equates to a half-life of greater than 1 year at 25 °C.
Validity criteria fulfilled:
yes
Conclusions:
Benzenebutanoic acid, 4-methyl-γ-oxo and 4-ethylmorpholine in the test material have been found to undergo less than 10 % hydrolysis after 5 days at 50 °C in pH 4, 7 and 9 buffer solutions which equates to a half-life of greater than 1 year at 25 °C.

Description of key information

Benzenebutanoic acid, 4-methyl-γ-oxo and 4-ethylmorpholine in the test material have been found to undergo less than 10 % hydrolysis after 5 days at 50 °C in pH 4, 7 and 9 buffer solutions, which equates to a half-life of greater than 1 year at 25 °C.

Key value for chemical safety assessment

Half-life for hydrolysis:
365 d
at the temperature of:
25 °C

Additional information