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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05 April 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
isoteniscope
Key result
Temp.:
20 °C
Vapour pressure:
0.22 kPa
Key result
Temp.:
25 °C
Vapour pressure:
0.29 kPa

Table 1: Vapour pressure of the test material at various temperatures

Temperature (°C)

Vapour Pressure 1 (kPa)

Vapour Pressure 2 (kPa)

Vapour Pressure 3 (kPa)

Mean (kPa)

20

0.06*

0.03*

0.07*

0.05*

25

0.15*

0.14*

0.16*

0.15*

30

0.22*

0.28*

0.25*

0.25*

35

0.40*

0.41*

0.39*

0.40*

40

0.67

0.60

0.59

0.62

45

0.92

0.85

0.84

0.87

50

1.22

1.14

1.14

1.17

55

1.57

1.53

1.55

1.55

60

2.05

2.03

2.01

2.03

65

2.67

2.58

2.59

2.61

70

3.34

3.23

3.23

3.27

75

4.09

3.98

4.01

4.03

80

5.02

4.86

4.90

4.93

85

6.01

5.83

5.91

5.92

90

7.18

6.95

7.00

7.04

95

8.51

8.21

8.31

8.34

100

9.96

9.64

9.80

9.80

* below the quantitation limit

Based on the simplified Clausius-Clapeyron equation a regression line was fitted on the measured data and the vapour pressure was extrapolated for 20 and 25°C:

20°C: 0.22 kPa

25°C: 0.29 kPa

Conclusions:
Under the conditions of this study, the vapour pressure of the test material was 0.22 kPa at 20°C and 0.29 kPa at 25°C.
Executive summary:

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4, under GLP conditions.

The vapour pressure was determined using the isoteniscope principle. Based on the simplified Clausius-Clapeyron equation a regression line was fitted on the measured data and the vapour pressure was extrapolated for 20 and 25°C.

Under the conditions of this study, the vapour pressure of the test material was 0.22 kPa at 20°C and 0.29 kPa at 25°C.

Description of key information

Under the conditions of the study, the vapour pressure of the test material was 0.22 kPa at 20°C and 0.29 kPa at 25°C.

Key value for chemical safety assessment

Vapour pressure:
0.22 kPa
at the temperature of:
20 °C

Additional information

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The vapour pressure was determined using the isoteniscope principle. Based on the simplified Clausius-Clapeyron equation a regression line was fitted on the measured data and the vapour pressure was extrapolated for 20 and 25°C.

Under the conditions of this study, the vapour pressure of the test material was 0.22 kPa at 20°C and 0.29 kPa at 25°C.