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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 April 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
other: capillary method
Key result
Boiling pt.:
333.8 °C
Atm. press.:
98.7 kPa
Decomposition:
no
Remarks on result:
other: ± 0.17°C (95% confidence interval)

The test was carried out at 98.7 kPa atmospheric pressure. Using a linear heating rate of 0.5°C/min, the boiling point of the test material was found to be 333.8 ± 0.17°C (95% confidence interval), i.e. 607.0 K.

 

Table 1:Measured temperatures corresponding to the boiling point of the test material (three experiments (I, II, III) with two parallel samples each (1, 2)

 

Measured Temperatures during the Main Study (°C)

I/1

I/2

II/1

II/2

III/1

III/2

Mean

Boiling Point

334.0

334.0

333.9

333.6

333.7

333.7

333.8

Conclusions:
Under the conditions of this study, the boiling point of the test material was found to be 333.8 ± 0.17°C (95% confidence interval).
Executive summary:

The boiling point of the test material was investigated in accordance with the standardised guidelines OECD 103 and EU Method A.2, under GLP conditions.

A preliminary test with two parallel samples was performed at 10°C/min heating rate from the melting point to 400°C. In the main test, two capillaries containing the test material were placed into the apparatus and the block was heated from 325 to 340°C at a 0.5°C/min heating rate. The sample was observed visually through the magnifying glass. The end temperature was registered when a quick continuous flow of bubbles was formed at the plunged-in end of the capillary. The experiment was repeated three times with two parallel measurements each. The mean of the six measurements was reported.

Under the conditions of this study, the boiling point of the test material was found to be 333.8 ± 0.17°C (95% confidence interval).

Description of key information

Under the conditions of the study, the boiling point of the test material was found to be 333.8 ± 0.17°C (95% confidence interval).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
333.8 °C

Additional information

The boiling point of the test material was investigated in accordance with the standardised guidelines OECD 103 and EU Method A.2, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

A preliminary test with two parallel samples was performed at 10°C/min heating rate from the melting point to 400°C. In the main test, two capillaries containing the test material were placed into the apparatus and the block was heated from 325 to 340°C at a 0.5°C/min heating rate. The sample was observed visually through the magnifying glass. The end temperature was registered when a quick continuous flow of bubbles was formed at the plunged-in end of the capillary. The experiment was repeated three times with two parallel measurements each. The mean of the six measurements was reported.

Under the conditions of the study, the boiling point of the test material was found to be 333.8 ± 0.17°C (95% confidence interval).