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EC number: 309-811-7
CAS number: 101033-44-7
No studies were
conducted on the target substance, Tetrakis
[[2,2',2"-nitrilotris[ethanolato]](1-)-N,O]zirconium. As the target
substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic
properties are related to hydrolysis products of the target substance,
there were no signs of systemic toxicity in studies amongst rats and
mice of up to 90 days duration with exposure levels up to 2000 mg/kg/day
in rats and 4000 mg/kg/day in mice. There were signs of local irritation
(mild hyperplasia) at approximately 125 mg/kg/day and above. Systemic
NOAEL was set 250 mg/kg bw/day (rats).
repeated oral exposure, the most reliable studies amongst rats and mice
indicate that a NOAEL is of the order of 1000 mg/kg/day (for studies up
to 90 days duration). Above this exposure level some signs of systemic
toxicity are apparent, being manifested by unspecified changes to the
liver and kidney. Administration by drinking water gave NOAELs of 2400
mg/kg/day or more amongst rats and mice in a 14 day study.
Based on the NOAEL
(oral), NOAEC (inhalation) and NOAEL (dermal) of triethanolamine, there
is no need for classification of the target substance in accordance with
the criteria of CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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