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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Final report on the safety assessment of triethanolamine, diethanolamine, and monoethanolamine
Author:
Cosmetic Ingredient Review
Year:
1983
Bibliographic source:
J. Amer. Coll. Toxicol. 2 (7) 173-235

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24h
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
3

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
0
Clinical signs:
TEA elicited mild erythema and no edema at 24 h and the skin returned to normal by Day 6. The 91.8% TEA produced moderate erythema and no edema at 24 h and the treated sites were normal by Day 10.
Body weight:
The animals were observed for 14 days. All rabbits gained weight and none died.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The dermal LD50 on rabbits was greater than 2000 mg/kg bw, and was classified as Category 5 according ly GHS criteria.
Executive summary:

As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.