Registration Dossier
Registration Dossier
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EC number: 204-586-0 | CAS number: 122-96-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: HPV report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Piperazine-1,4-diethanol
- EC Number:
- 204-586-0
- EC Name:
- Piperazine-1,4-diethanol
- Cas Number:
- 122-96-3
- Molecular formula:
- C8H18N2O2
- IUPAC Name:
- 1,4-Bis(2-hydroxyethyl)piperazine
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4h
- Observation period:
- 72h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Reversibility:
- fully reversible
- Remarks on result:
- other: Slight erythema was observed 1 hour after the exposure period in each rabbit. By 24 hours after the exposue, each rabbit appeared normal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not irritating.
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