Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-586-0 | CAS number: 122-96-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr. Ph.D., etc.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 23:2, 95-107. https://doi.org/10.1080/00028896209343211
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: one-day cuff method of Draize and associates
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Piperazine-1,4-diethanol
- EC Number:
- 204-586-0
- EC Name:
- Piperazine-1,4-diethanol
- Cas Number:
- 122-96-3
- Molecular formula:
- C8H18N2O2
- IUPAC Name:
- 1,4-Bis(2-hydroxyethyl)piperazine
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Duration of exposure:
- 24 h
- Doses:
- 10 ml/kg
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
