Pent-4-enoyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Food flavourings and compounds of related structure - I. Acute oral toxicity

Author:

P.M.Jenner, E.C. Hagan, Jean M. Taylor, E.L. Cook and O.G. Fritzhugh

Year:

1964

Bibliographic source:

Fd Cosmet. Toxicol. Vol.2, pp. 327-343

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pent-4-enoic acid

EC Number:

209-732-7

EC Name:

Pent-4-enoic acid

Cas Number:

591-80-0

Molecular formula:

C5H8O2

IUPAC Name:

pent-4-enoic acid

Details on test material:

- Name of test material: Allylacetic acid (pentenoic acid)
- Substance type: no data
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: 18 hours
- Housing:no data
- Diet: no data
- Water: ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod: no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: no data
- Amount of vehicle (if gavage): no data
- Justification for choice of vehicle: no data
- Lot/batch no. (if required): no data
- Purity: no data

MAXIMUM DOSE VOLUME APPLIED:
no data

Doses:

no data

No. of animals per sex per dose:

5 animals per dose per sex

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs

Statistics:

LD50 was calculated according to the method of Litchfield & Wilcoxon.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

470 mg/kg bw

95% CL:

385 - 573

Mortality:

no data

Clinical signs:

other: Depression within 30 min. High dose caused convulsion.

Gross pathology:

no data

Other findings:

Most rats that recover appear normal the day following treatment.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Remarks:

Migrated information

Conclusions:

5-Pentenoic acid is harmful if swallowed.