Amines, C12-14-branched alkyl, dodecylbenzenesulfonates (1:1)

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24 July 2017 - 03 November 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Preliminary test, in accordance with EU Method A.6.. The test item is a surface active substance with an extremely complex composition consisting of multiple constituent groups. Neither the column elution method nor shake flask method were deemed suitable for a substance of this nature. Potentially inaccurate water solubility values were anticipated due to emulsification (shake-flask method) or secondary interactions (column elution method). It was therefore believed that a screening approach, using the preliminary test described in the guideline would yield the most reliable and representative water solubility value for this test item. It should be noted that comparable solubility values were achieved in aqueous media when the test item underwent aquatic ecotoxicological testing.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Regulation (EC) 440/2008 of 30 May 2008

Deviations:

no

Remarks:

Preliminary test performed in accordance with method described in guideline.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

July 1995

Deviations:

no

Remarks:

Preliminary test performed in accordance with method described in guideline.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Visual observation.

Remarks:

As per the preliminary test method described in EU Method A.6. and OECD 105.

Key result

Water solubility:

>= 10 - <= 22 mg/L

Temp.:

21.1 °C

pH:

7.32

Table 1:          Test results first determination (at 21.1 °C)

Weight Test Item [mg]	Volume of ultra-pure water [mL]	Shaking Duration [min]	Remarks
11	100	10	not dissolved, no light scattering
	200	10	not dissolved, no light scattering
	500	10	not dissolved, no light scattering
	1000	10	not dissolved, no light scattering
	1100	10	not dissolved, no light scattering
	1100	27 h	dissolved completely, no light scattering, foaming, pH = 7.32, solubility ≥ 10 mg/L

 

 

Table 2:          Test results second determination (at 22.4 °C)

Weight Test Item [mg]	Volume of ultra-pure water [mL]	Shaking Duration [min]	Remarks
11	500	30	not dissolved, no light scattering
	500	60	not dissolved, no light scattering
	500	18 h	not dissolved, no light scattering
	500	24 h	not dissolved, no light scattering, solubility < 22 mg/L

 

The second determination was performed to exclude that the test item can be dissolved at a concentration of 22 mg/L if shaking time is prolonged up to 24 hours. After 24 hours, a solubility check was conducted. The test item had not dissolved. In the opinion of expert judgement, the test item was not expected to dissolve with further agitation. The second determination was therefore stopped after 24 hours.

 

Solubility of Amines, C12-14-branched alkyl, dodecylbenzenesulfonates (1:1) in ultra-pure water at 21.1 °C is determined to be between 10 and 22 mg/L. The pH of the solution was 7.32.

Conclusions:

Water solubility in ultra-pure grade water at 21.1 °C was determined to be between 10 and 22 mg/L. The pH of the solution was 7.32.

Executive summary:

EU Method A.6. – The water solubility of the test item was determined utilising a visual assessment approach (preliminary test).  The procedure employed was designed to be compatible with Method A.6., Water Solubility, of Commission Regulation (EC) No 440/2008 of 30 May 2008.

An appropriate amount of the test item was given into a glass vessel and the amount of water was increased stepwise.  After each addition of water, the mixture was vigorously shaken for at least 10 min and was visually checked for undissolved parts of the sample.  As the solubility of the test item was low the time to dissolve was prolonged to at least 24 hours.  The water solubility of the test item was determined twice.

The water solubility of the test item in ultra-pure water was determined to be between 10 and 22 mg/l at 21.1 °C and pH 7.32.

Description of key information

Water Solubility: 10 - 22 mg/l at 21.1 °C and pH 7.32; EU Method A.6.; C Bär (2017)

Key value for chemical safety assessment

Water solubility:

16 mg/L

at the temperature of:

21.1 °C

Additional information

EU Method A.6. – The water solubility of the test item was determined utilising a visual assessment approach (preliminary test).  The procedure employed was designed to be compatible with Method A.6., Water Solubility, of Commission Regulation (EC) No 440/2008 of 30 May 2008.

An appropriate amount of the test item was given into a glass vessel and the amount of water was increased stepwise.  After each addition of water, the mixture was vigorously shaken for at least 10 min and was visually checked for undissolved parts of the sample.  As the solubility of the test item was low the time to dissolve was prolonged to at least 24 hours.  The water solubility of the test item was determined twice.

The water solubility of the test item in ultra-pure water was determined to be between 10 and 22 mg/l at 21.1 °C and pH 7.32.