Registration Dossier
Registration Dossier
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EC number: 203-317-4 | CAS number: 105-64-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The effect of diisopropyl peroxydicarbonate on the respiration of activated sewage sludge has been assessed according to OECD 209 and gave a 3-hour EC50 value of 40 mg/L and a 3-hour EC10 of 9.9 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 40 mg/L
- EC10 or NOEC for microorganisms:
- 9.9 mg/L
Additional information
A study was performed to assess the effect of diisopropyl peroxydicarbonate on the respiration of activated sewage sludge according to OECD test guideline 209 and in accordance with GLP (Best, 2017).
Following a preliminary range-finding test, activated sewage sludge was exposed to an aqueous dispersion of the test item at concentrations of 5.6, 10, 18, 32 and 56 mg/L (5 replicates per concentration) for a period of 3 hours at measured temperatures of 20 ± 1 °C with the addition of a synthetic sewage as a respiratory substrate.
The rate of respiration was determined after 3 hours contact time and compared to data for the control and a reference item, 3,5-Dichlorophenol. As the test item corresponds to 59.3% of diisopropyl peroxydicarbonate in 49.7% of ethyl acetate, the control and reference item vessels were prepared with the same concentration of ethyl acetate as present in the highest tested concentration.
The effect of diisopropyl peroxydicarbonate on the respiration of activated sewage sludge gave a 3-hour EC50 value of 40 mg/L and a 3-hour EC10 of 9.9 mg/L. The NOEC after 3 hours exposure was 18 mg/L. All the validity criteria were fulfilled.
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