Registration Dossier
Registration Dossier
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EC number: 252-390-9 | CAS number: 35141-30-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 16 h
- Dose descriptor:
- EC10
- Effect conc.:
- 25 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Duration:
- 16 h
- Dose descriptor:
- EC50
- Effect conc.:
- 67 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Conclusions:
- One study is available for the source substance CAS 1760-24-3. A 16 hour EC50 value of 67 mg/l and an EC10 value of 25 mg/l were determined for toxicity to pseudomonas putida (growth rate) in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. As explained in the attached justification, similar results are expected by the target substance.
Reference
Description of key information
EC10 (16 h) = 25 mg/L (nominal, OECD 209) based on read across from CAS 1760-24-3.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 67 mg/L
- EC10 or NOEC for microorganisms:
- 25 mg/L
Additional information
Experimental data on the toxicity of N-(2-aminoethyl)-N’-[3-(trimethoxysilyl)propyl]ethylenediamine (CAS 35141-30-1) towards microorganisms are not available. Therefore, in accordance with the Regulation (EC) No. 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and the read across assessment framework (RAAF, ECHA 2017) a read across from the analogue substance N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (CAS 1760-24-3) has been performed. Details on the read-across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
The influence of the analogue substance on the growth of Pseudomonas putida was examined in a reliable study conducted according to DIN 38412/8 and GLP (1994). The nominal test concentrations were 15.6, 31.3, 50, 62.5, 125, 250 and 500 mg/L. An EC50 (16 h) of 67 mg/L and an EC10 (16 h) of 25 mg/L based on growth inhibition, were determined in the test.
Based on the results of the analogue substance and the attached read across justification, similar effects are expected by the target substance N-(2-aminoethyl)-N’-[3-(trimethoxysilyl)propyl]ethylenediamine (CAS 35141-30-1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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