Registration Dossier
Registration Dossier
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EC number: 252-390-9 | CAS number: 35141-30-1
Endpoint summary
Administrative data
Description of key information
Additional information
Suitable experimental data testing the toxicity of N-(2-aminoethyl)-N’-[3-(trimethoxysilyl)propyl]ethylenediamine (CAS 35141-30-1) towards aquatic organisms were not available. Therefore appropriate read across data from N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (CAS 1760-24-3) were used. Information on the read across approach can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
All studies with the target and the source substances were performed according to appropriate OECD or EU guidelines and mostly GLP standards.
Short term results showed that algae is the most sensitive species (ErC50 (72 h) = 8.8 mg/L) followed by aquatic invertebrates (EC50 (48 h) = 81 mg/L) while only slight effects at very high concentrations (>100 mg/L) were recorded for fish (EC50 (96 h) = 597 mg/L). Long term data were available only for algae with a NOErC (72 h) of 3.1 mg/L (nominal).
Furthermore the study with the source substance N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (CAS 1760-24-3) and Pseudomonas putida resulted in growth inhibition values of 67 mg/L (EC50) and 25 mg/L (EC10) after 16 h of exposure.
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